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Scholar Results 1 - 10 of about 101 related to Greene: Claims of equivalence in medical research: are they supported by the evidence?. (0.10 sec) 

Claims of equivalence in medical research: are they supported by the evidence?

- annals.org [PDF] 
WL Greene, J Concato, AR Feinstein - Annals of internal medicine, 2000 - Am Coll Physicians
William L. Greene, MD; John Concato, MD, MPH; and Alvan R. Feinstein, MD ...
Background: Most clinical studies are done to show comparative superiority, but
many reports now claim equivalence between the investigated entities. These ...
Cited by 114 - Related articles - BL Direct - All 4 versions

Scientific and ethical issues in equivalence trials


B Djulbegovic, M Clarke - Jama, 2001 - Am Med Assoc
The article by Staszewski et al 2 in this issue of THE JOURNAL is a randomized
controlled equivalence trial that compares a triple nucleoside regimen of
abacavir-lamivudine-zidovudine with a more conventional regimen of ...
Cited by 49 - Related articles - All 2 versions

Active-control equivalence trials and antihypertensive agents


FA McAlister, DL Sackett - The American journal of medicine, 2001 - Elsevier
Standard methodological criteria for randomized clinical trials and six
additional methodological features that affect the validity of active-control
equivalence trials were applied to four recently published large trials ...
Cited by 50 - Related articles - BL Direct - All 7 versions

Trials to assess equivalence: the importance of rigorous methods

- bmj.com
B Jones, P Jarvis, JA Lewis, AF Ebbutt - British Medical Journal, 1996 - bmj.com
The aim of an equivalence trial is to show the therapeutic equivalence of two
treatments, usually a new drug under development and an existing drug for the
same disease used as a standard active comparator. Unfortunately the ...
Cited by 546 - Related articles - BL Direct - All 9 versions

Equivalence trials


JH Ware, EM Antman - New England Journal of Medicine, 1997 - content.nejm.org
In the typical two-group clinical trial with outcomes of either success or
failure, investigators are interested in finding out whether an innovative
treatment, T, reduces the frequency of failure relative to standard ...
Cited by 103 - Related articles - BL Direct - All 5 versions

Absence of evidence is not evidence of absence.

- nih.gov [PDF] 
DG Altman, JM Bland - BMJ: British Medical Journal, 1995 - pubmedcentral.nih.gov
13 Chen RT, Weierbach R, Bisoffi Z, Cutts F, Rhodes P, Ramaroson S, et al. A
"post-honeymoon period" measles outbreak in Muyinga Sector, Burundi.
IntrEpidemiol 1994;23:185-93. 14 Holt EA, Boulos R, Halsey NA, Boulos IM, ...
Cited by 357 - Related articles - BL Direct - All 9 versions

Practical issues in equivalence trials


AF Ebbutt, L Frith - Statistics in Medicine, 1998 - interscience.wiley.com
Equivalence trials aim to show that two treatments have equivalent therapeutic
effects. The approach is to define, in advance, a range of equivalence -d to +d
for the treatment difference such that any value in the range is clinically ...
Cited by 90 - Related articles - BL Direct - All 3 versions

[PDF] La ausencia de significación estadística en un ensayo clínico no significa equivalencia …


JM Argimon - Med Clin (Barc), 2002 - udomfyc.org
«La ausencia de evidencia no es evidencia de ausencia.» Éste fue el título
que Altman y Bland1 eligieron para un artí- culo en el que alertaban sobre un
error común en la biblio- grafía biomédica: interpretar un resultado ...
Cited by 7 - Related articles - All 4 versions

Claims of equivalence in randomized controlled trials of the treatment of bacterial meningitis …


DJ Krysan, AR Kemper - The Pediatric infectious disease journal, 2002 - journals.lww.com
Methods. We performed a systematic review of randomized controlled trials of
antimicrobial therapy for bacterial meningitis in children indexed in MEDLINE
and published after 1980 and that claimed equivalency. The sample size of ...
Cited by 14 - Related articles - BL Direct - All 4 versions

[PDF] Non-inferiority trials: design concepts and issues-the encounters of academic consultants in …


RB D'Agostino, JM Massaro, LM Sullivan - Statistics in Medicine, 2002 - haberle.com
STATISTICS IN MEDICINE Statist. Med. 2003; 22:169–186 (DOI: 10.1002/sim.1425)
... Non-inferiority trials: design concepts and issues – the encounters of
academic consultants in statistics ... Ralph B. D'Agostino Sr.1;2;∗;† ...
Cited by 128 - Related articles - View as HTML - BL Direct - All 8 versions


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