- ►annals.org R Temple, SS Ellenberg - Annals of Internal Medicine, 2000 - Am Coll Physicians In recent years, several authors have argued that placebo-controlled trials are
invariably unethical when known effective therapy is available for the condition
being studied, regardless of the condition or the consequences of deferring ... Cited by 395 - Related articles - BL Direct - All 9 versions
- ►annals.org SS Ellenberg, R Temple - Annals of Internal Medicine, 2000 - Am Coll Physicians Placebo controls are commonly used in clinical trials of investigational
treatments because they have important advantages. In recent years, some have
criticized the use of placebo-controlled trials when effective alternative ... Cited by 164 - Related articles - BL Direct - All 7 versions
KJ Rothman, KB Michels - The New England journal of medicine, 1994 - nejm.highwire.org The Nuremberg Code, "the cornerstone of modern human experimentation ethics," 2
was formulated shortly after World War II in response to Nazi atrocities. The
World Health Organization adopted a version of the code in 1964 as the ... Cited by 474 - Related articles - BL Direct - All 5 versions
EJ Emanuel, FG Miller - The New England journal of medicine, 2001 - nejm.highwire.org The first placebo-controlled trial was probably conducted in 1931, when
sanocrysin was compared with distilled water for the treatment of tuberculosis.
1 Ever since then, placebo-controlled trials have been controversial, ... Cited by 164 - Related articles - BL Direct - All 16 versions
- ►uwo.ca [PDF] B Freedman, KC Glass, C Weijer - JL Med. & Ethics, 1996 - heinonlinebackup.com Myth I: The real problem is the Helsinki Declaration In their attack on the
prevailing use of placebo controls, Kenneth Rothman and Karin Michelse emphasize
that this practice stands in violation of the World Medical Associa- tion's ... Cited by 104 - Related articles - BL Direct - All 4 versions
V Hasselblad, DF Kong - Drug Information Journal, 2001 - cat.inist.fr There has been a proliferation of active-control clinical trials comparing
experimental therapies with standard ones(active control). In such cases, one
often wants to know how the experimental therapy would have performed if it ... Cited by 64 - Related articles - BL Direct - All 3 versions
- ►uwo.ca [PDF] B Freedman, C Weijer, KC Glass - JL Med. & Ethics, 1996 - heinonlinebackup.com Myth I: Placebo-controlled trials have proven over the last decades to provide
an accurate baseline measure of a treatment's biological effectiveness One major
methodological advance in medical science since World War II is the ... Cited by 83 - Related articles - BL Direct - All 4 versions
D Orentlicher - Diabetes care, 2001 - Am Diabetes Assoc Much controversy exists regarding the ethics of placebo-controlled trials in
which an experimental therapy will compete with an already established treatment
(or treatments). In such cases, argue critics, patients in the control arm ... Cited by 4 - Related articles - BL Direct - All 5 versions
HMJ Hung, SJ Wang, Y Tsong, J Lawrence, RT O … - Proceedings of the Annual Meeting of the American …, 2001 - amstat.org 1. INTRODUCTION Non-inferiority testing for therapeutic effectiveness in active
controlled clinical trials is often controversial despite the fact that there is
considerable practical experience in using this approach to establish the ... Cited by 73 - Related articles - View as HTML - BL Direct - All 6 versions
- ►bmj.com B Jones, P Jarvis, JA Lewis, AF Ebbutt - British Medical Journal, 1996 - bmj.com The aim of an equivalence trial is to show the therapeutic equivalence of two
treatments, usually a new drug under development and an existing drug for the
same disease used as a standard active comparator. Unfortunately the ... Cited by 545 - Related articles - BL Direct - All 9 versions
