- ►annals.org SS Ellenberg, R Temple - Annals of Internal Medicine, 2000 - Am Coll Physicians Placebo controls are commonly used in clinical trials of investigational
treatments because they have important advantages. In recent years, some have
criticized the use of placebo-controlled trials when effective alternative ... Cited by 166 - Related articles - BL Direct - All 7 versions
- ►annals.org R Temple, SS Ellenberg - Annals of Internal Medicine, 2000 - Am Coll Physicians In recent years, several authors have argued that placebo-controlled trials are
invariably unethical when known effective therapy is available for the condition
being studied, regardless of the condition or the consequences of deferring ... Cited by 396 - Related articles - BL Direct - All 9 versions
V Hasselblad, DF Kong - Drug Information Journal, 2001 - cat.inist.fr There has been a proliferation of active-control clinical trials comparing
experimental therapies with standard ones(active control). In such cases, one
often wants to know how the experimental therapy would have performed if it ... Cited by 64 - Related articles - BL Direct - All 3 versions
JP Siegel - American Heart Journal, 2000 - Elsevier Equivalence and noriinferiority trials jay P. Siegel, O Rockvige, Md Terminology
ign, conduct, and analysis of trials intended to show that a given treatment
produces an effect similar to that of an alternative treatment raise many ... Cited by 76 - Related articles - BL Direct - All 6 versions
TR Fleming - American Heart Journal, 2000 - Elsevier Design and interpretation of equivalence trials Thomas R. F1eOg, PhD Seattle,
Wash icacy of a new therapeutic agent would be established if its treatment
effects prove to be at least equivalent to those observed from a ... Cited by 44 - Related articles - BL Direct - All 6 versions
HMJ Hung, SJ Wang, Y Tsong, J Lawrence, RT O … - Proceedings of the Annual Meeting of the American …, 2001 - amstat.org 1. INTRODUCTION Non-inferiority testing for therapeutic effectiveness in active
controlled clinical trials is often controversial despite the fact that there is
considerable practical experience in using this approach to establish the ... Cited by 73 - Related articles - View as HTML - BL Direct - All 6 versions
SJ Wang, HMJ Hung, Y Tsong - Controlled clinical trials, 2002 - Elsevier Increasingly often, the study objective in an active controlled clinical trial
without a placebo arm is to show that a new treatment is no less effective than
the active control treatment within some noninferiority range. Two issues ... Cited by 40 - Related articles - BL Direct - All 7 versions
- ►annals.org R Simon - Annals of Internal Medicine, 2000 - Am Coll Physicians The randomized clinical trial was a major methodologic breakthrough in medicine.
For conditions having no effective treatment, the control regimen to which the
new treatment is compared is usually either observation or administration ... Cited by 26 - Related articles - BL Direct - All 3 versions
EJ Emanuel, FG Miller - The New England journal of medicine, 2001 - nejm.highwire.org The first placebo-controlled trial was probably conducted in 1931, when
sanocrysin was compared with distilled water for the treatment of tuberculosis.
1 Ever since then, placebo-controlled trials have been controversial, ... Cited by 164 - Related articles - BL Direct - All 16 versions
EB Holmgren - Journal of Biopharmaceutical Statistics, 1999 - ncbi.nlm.nih.gov We propose a procedure for establishing equivalence that determines whether a
specified percentage of the treatment effect of a known active agent over
placebo is maintained. This procedure accounts for the error in the ... Cited by 48 - Related articles - BL Direct - All 2 versions
