- ►annals.org [PDF] V Santini, HM Kantarjian, JP Issa - Annals of internal medicine, 2001 - Am Coll Physicians Methylation of DNA is a biochemical modification that can influ- ence gene
expression and is involved in inactivating one of the two X chromosomes in
women. Evidence that has accumulated in the past 10 years suggests that ... Cited by 294 - Related articles - BL Direct - All 4 versions
- ►jcojournal.org P Wijermans, M Lubbert, G Verhoef, A Bosly, … - Journal of Clinical Oncology, 2000 - jcojournal.org PATIENTS AND METHODS: Between June 1996 and September 1997, 66 patients (median
age, 68 years) from seven centers received DAC 45 mg/m 2 /d for 3 days every 6
weeks. For patients in whom a complete response (CR) was reached after two ... Cited by 372 - Related articles - BL Direct - All 9 versions
- ►hematologylibrary.org - Free from Publisher JPJ Issa, G Garcia-Manero, FJ Giles, R … - Blood, 2004 - bloodjournal.hematologylibrary.org Decitabine (5-aza-2'-deoxycytidine) inhibits DNA methylation and has dual
effects on neoplastic cells, including the reactivation of silenced genes and
differentiation at low doses and cytotoxicity at high doses. We evaluated, ... Cited by 326 - Related articles - BL Direct - All 7 versions
R Jüttermann, E Li, R Jaenisch - PROCEEDINGS-NATIONAL ACADEMY OF SCIENCES …, 1994 - National Acad Sciences Proc. Nati. Acad. Sci. USA Vol. 91, pp. 11797-11801, December 1994 Medical
Sciences ... Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated ... RUTH JLTTERMANN, EN LI*, AND RUDOLF JAENISCH Whitehead Institute for ... Cited by 322 - Related articles - BL Direct - All 6 versions
- ►bloodjournal.org M Daskalakis, TT Nguyen, C Nguyen, P … - Blood, 2002 - Am Soc Hematology The 5-methylcytosine distribution patterns in DNA are frequently altered during
cellular transformation. 1 CpG island hypermethylation can coexist with global
or gene-specific demethylation in malignant cells, 2-5 resulting in ... Cited by 282 - Related articles - BL Direct - All 5 versions
- ►haematologica.it [PDF] G Leone, L Teofili, MT Voso, M Lubbert - Haematologica, 2002 - haematologica.it Background and Objectives. Methylation of DNA is a common epigenetic
modification that plays an important role in the control of gene expression in
mammalian cells. This process involves CpG dinucleotide sequences and is ... Cited by 91 - Related articles - BL Direct - All 16 versions
- ►jcojournal.org LR Silverman, EP Demakos, BL Peterson, AB … - Journal of Clinical Oncology, 2002 - jcojournal.org PATIENTS AND METHODS: A randomized controlled trial was undertaken in 191
patients with MDS to compare Aza C (75 mg/m 2 /d subcutaneously for 7 days every
28 days) with supportive care. MDS was defined by French-American-British ... Cited by 582 - Related articles - BL Direct - All 11 versions
R Abele, M Clavel, P Dodion, U Bruntsch, S … - European journal of cancer & clinical oncology, 1987 - cat.inist.fr The EORTC early clinical trials cooperative group experience with 5-aza-2'-
deoxycytidine(NSC 127716) in patients with colo-rectal, head and neck, renal ... Cited by 55 - Related articles - All 3 versions
J Goffin, E Eisenhauer - Annals of Oncology, 2002 - Eur Soc Med Oncology DNA methylation inhibitors have demonstrated the ability to inhibit
hypermethylation, restore suppressor gene expression and exert antitumor effects
in in vitro and in vivo laboratory models. Four inhibitors, which are ... Cited by 170 - Related articles - BL Direct - All 6 versions
