- ►annals.org [PDF] TE Warkentin, JG Kelton - Annals of Internal Medicine, 2001 - Am Coll Physicians Background: Heparin-induced thrombocytopenia is a prothrom- botic drug reaction
caused by platelet-activating antibodies that recognize complexes of platelet
factor 4 and heparin. Objective: To describe a syndrome termed ... Cited by 225 - Related articles - BL Direct - All 7 versions
L Rice, WK Attisha, JL Francis - Annals of Internal Medicine, 2003 - Am Coll Physicians TO THE EDITOR: There are 2 forms of heparin-induced thrombo- cytopenia. Type 1
is common and trivial. The incidence of heparin- induced thrombocytopenia type
2, which causes serious thrombosis in patients receiving full doses of ... Cited by 192 - Related articles - BL Direct - All 6 versions
- ►stanford.edu [PDF] TE Warkentin, JG Kelton - New England Journal of Medicine, 2001 - content.nejm.org ABSTRACT Background Heparin-induced thrombocytopenia is a relatively common
antibody-mediated drug reaction. We studied the temporal relation between
previous or current heparin therapy and the onset of heparin- induced ... Cited by 443 - Related articles - BL Direct - All 13 versions
N Lubenow, R Kempf, A Eichner, P Eichler, … - Chest, 2002 - ncbi.nlm.nih.gov STUDY OBJECTIVES: Heparin-induced thrombocytopenia (HIT) is an immune-mediated
adverse drug reaction associated with a decrease of platelet counts that usually
begins after at least 5 days of heparin treatment. Uncertainty exists about ... Cited by 130 - Related articles - BL Direct - All 2 versions
- ►bloodjournal.org TE Warkentin, JAI Sheppard, P Horsewood, … - Blood, 2000 - Am Soc Hematology Two general types of laboratory assay are used to confirm the diagnosis.
Activation assays, such as the platelet serotonin release assay, detect HIT-IgG
on the basis of their ability to activate platelets. 11-13 Antigen assays, ... Cited by 331 - Related articles - BL Direct - All 7 versions
TE Warkentin, JG Kelton - The American journal of medicine, 1996 - Elsevier Heparin-induced thrombocytopenia was associated with the development of new
venous thrombotic events and arterial thrombotic events in 78 and 18 patients,
respectively (ratio venous/arterial thrombosis = 4:1). Pulmonary embolism ... Cited by 488 - Related articles - BL Direct - All 6 versions
TE Warkentin - Archives of Pathology and Laboratory Medicine, 2002 - arpa.allenpress.com Archives of Pathology and Laboratory Medicine: Vol. 126, No. 11, pp.
1415–1423. ... Objective.—Heparin-induced thrombocytopenia (HIT) is an
antibody-mediated adverse drug reaction that paradoxically is associated ... Cited by 135 - Related articles - BL Direct - All 4 versions
- ►bloodjournal.org A Greinacher, P Eichler, N Lubenow, H … - Blood, 2000 - Am Soc Hematology Thrombin plays a central role in HIT-related thromboembolic complication (TEC).
Thrombin generation is enhanced in HIT by the concomitant activation of
platelets, 10 the generation of platelet microparticles, 11 and the ... Cited by 252 - Related articles - BL Direct - All 6 versions
DE Wallis, DL Workman, BE Lewis, L Steen, R … - The American journal of medicine, 1999 - Elsevier RESULTS: Of the 113 patients, 38% developed thrombosis and 27% died. One-half of
patients had thrombosis diagnosed >24 hours after heparin cessation. No
difference in thrombosis or mortality was found in the 40 patients with ... Cited by 233 - Related articles - BL Direct - All 6 versions
- ►osu.edu [PDF] TE Warkentin, RS Roberts, J Hirsh, JG Kelton - Archives of Internal Medicine, 2003 - archinte.highwire.org Background Diagnosis of immune heparin-induced thrombocytopenia (HIT) is usually
based on a fall in platelet count below 150 x 10 9 /L (standard definition of
thrombocytopenia). However, this definition may be inappropriate for ... Cited by 168 - Related articles - BL Direct - All 6 versions
