- ►annals.org NS Young - Annals of Internal Medicine, 2002 - Am Coll Physicians In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow
appears empty. The pathophysiology of aplastic anemia is now believed to be
immune-mediated, with active destruction of blood-forming cells by lymphocytes. The ... Cited by 241 - Related articles - BL Direct - All 15 versions
- ►ishapd.org [PDF] NS Young, J Maciejewski - The New England journal of medicine, 1997 - nejm.highwire.org Aplastic anemia, first described by Paul Ehrlich in 1888 from an autopsy of a young pregnant
woman who had died after a brief catastrophic illness, is the clearest example of failed hematopoiesis
in humans. It differs from agranulocytosis and pure red-cell aplasia, which involve only ... Cited by 342 - Related articles - BL Direct - All 9 versions
S Rosenfeld, D Follmann, O Nunez, NS Young - Jama, 2003 - Am Med Assoc You are seeing this message because your Web browser does not support basic Web
standards. Find out more about why this message is appearing and what you can do to make
your experience on this site better. ... Context In most patients, aplastic anemia results ... Cited by 123 - Related articles - BL Direct - All 4 versions
- ►bloodjournal.org E Sloand, S Kim, JP Maciejewski, J Tisdale, D … - Blood, 2002 - Am Soc Hematology Substantial clinical and experimental evidence suggests that the immune system plays an important
role in the pathophysiology of acquired aplastic anemia (AA). Various immunosuppressive
drugs, including antithymocyte globulin (ATG), cyclosporine (CSA), and high doses of ... Cited by 91 - Related articles - BL Direct - All 6 versions
KE Brown, J Tisdale, AJ Barrett, CE Dunbar, … - New England Journal …, 1997 - content.nejm.org Results Ten patients with hepatitis-associated aplastic anemia were referred to the NIH between
1990 and 1996; all had the typical features of this syndrome. There was evidence of activated
CD8 T lymphocytes in the blood. Serologic tests for hepatitis A, B, and C viruses were ... Cited by 161 - Related articles - BL Direct - All 6 versions
- ►hematologylibrary.org N Frickhofen, H Heimpel, JP Kaltwasser, H … - …, 2003 - bloodjournal.hematologylibrary.org Because HSCT cures aplastic anemia, it is the treatment of choice for young patients with suitable
stem cell donors. HLA-matched related donors are widely accepted as stem cell donors, 2 whereas
unrelated donor HSCT still carries a significant risk for morbidity and mortality. 3 Most ... Cited by 120 - Related articles - BL Direct - All 9 versions
RA Brodsky, RJ Jones - The Lancet, 2005 - Elsevier Aplastic anaemia is a rare haemopoietic stem-cell disorder that results in pancytopenia and hypocellular
bone marrow. Although most cases are acquired, there are unusual inherited forms. The pathophysiology
of acquired aplastic anaemia is immune mediated in most cases; autoreactive ... Cited by 83 - Related articles - All 8 versions
JP Maciejewski, C Rivera, H Kook, D … - British journal of …, 2001 - interscience.wiley.com Because of the insensitivity of the Ham test, paroxysmal nocturnal haemoglobinuria (PNH) has
been inaccurately viewed as a late clonal complication of aplastic anaemia (AA). To clarify the
relationship between PNH and marrow failure, we tested for the presence of ... Cited by 81 - Related articles - BL Direct - All 4 versions
