- ►annals.org [PDF] MJ Krantz, L Lewkowiez, H Hays, MA … - Annals of internal medicine, 2002 - Am Coll Physicians Torsade de Pointes Associated with Very-High-Dose Methadone ... Mori J. Krantz,
MD; Laurent Lewkowiez, MD; Helen Hays, MD; Mary Ann Woodroffe, BScN; Alastair D.
Robertson, PhD; and Philip S. Mehler, MD ... Background: Methadone is an ... Cited by 196 - Related articles - All 9 versions
MJ Krantz, IB Kutinsky, AD Robertson, PS … - Pharmacotherapy, 2003 - PPI A prolonged corrected QT (QTc) interval is an established marker of arrhythmia
risk, primarily for a form of polymorphic ventricular tachycardia known as
torsade de pointes. Many anti- arrhythmic drugs exhibit dose-related ... Cited by 81 - Related articles - BL Direct - All 6 versions
- ►capitalhospice.org [PDF] CA Kornick, MJ Kilborn, J Santiago-Palma, G … - Pain, 2003 - Elsevier Numerous medications prolong the rate-corrected QT (QTc) interval and induce
arrhythmias by blocking ionic current through cardiac potassium channels
composed of subunits expressed by the human ether-a-go-go-related gene ... Cited by 85 - Related articles - All 10 versions
PW Walker, D Klein, L Kasza - Pain, 2003 - Elsevier Three patients who developed torsades de pointes while receiving high dosages of
oral methadone (>600 mg/day) are presented. In all of the cases, drug
interactions involving methadone and CYP3A4 isoenzyme system were possible. ... Cited by 60 - Related articles - All 7 versions
M Gil, M Sala, I Anguera, O Chapinal, M … - The American journal of cardiology, 2003 - Elsevier The introduction of highly active antiretroviral therapy for the treatment of
human immunodeficiency virus (HIV) infection has increased drug interactions due
to the induction and/or inhibition of cytochrome P450. Pharmacokinetic ... Cited by 71 - Related articles - All 10 versions
- ►aspetjournals.org AN Katchman, KA McGroary, MJ Kilborn, CA … - Journal of Pharmacology and Experimental …, 2002 - ASPET We have evaluated the ability of various opioid agonists, including methadone,
L- -acetylmethadol (LAAM), fentanyl, meperidine, codeine, morphine, and
buprenorphine, to block the cardiac human ether-a-go-go-related gene (HERG) ... Cited by 90 - Related articles - BL Direct - All 3 versions
BA Martell, JH Arnsten, B Ray, MN Gourevitch - Annals of internal medicine, 2003 - ncbi.nlm.nih.gov 1: Ann Intern Med. 2003 Jul 15;139(2):154-5. The impact of methadone induction
on cardiac conduction in opiate users. Martell BA ... Cited by 50 - Related articles - BL Direct - All 2 versions
- ►pharmacoclean.ch [PDF] GB Ehret, C Voide, M Gex-Fabry, J Chabert, D … - Archives of Internal Medicine, 2006 - archinte.highwire.org Methods We performed a systematic, retrospective study comparing active or
former intravenous drug users receiving methadone and those not receiving
methadone among all patients hospitalized over a 5-year period in a ... Cited by 70 - Related articles - BL Direct - All 8 versions
I Maremmani, M Pacini, C Cesaroni, M … - Eur Addict Res, 2005 - content.karger.com Icro Maremmani, MD Department of Psychiatry, NFB, 'Santa Chiara', University
Hospital University of Pisa Via Roma 67, IT–56100 Pisa (Italy) Tel. +39
050993045, Fax +39 05021581, E-Mail maremman@psico.med.unipi.it Cited by 47 - Related articles - BL Direct - All 4 versions
BA Martell, JH Arnsten, MJ Krantz, MN … - The American journal of cardiology, 2005 - Elsevier An increase in methadone-related deaths has recently been reported. 1 and 2
Although these deaths are generally caused by overdoses involving multiple
substances, reports of Torsade de pointes associated with methadone suggest ... Cited by 44 - Related articles - All 7 versions
