- ►annals.org [PDF] R Kurzrock, HM Kantarjian, BJ Druker, M … - Annals of internal medicine, 2003 - Am Coll Physicians The Philadelphia chromosome translocation (t(9;22)) results in the molecular
juxtaposition of two genes, BCR and ABL, to form an aberrant BCR-ABL gene on
chromosome 22. BCR-ABL is critical to the pathogenesis of chronic ... Cited by 121 - Related articles - BL Direct - All 10 versions
ALM García, F de Ciencias, C de … - javeriana.edu.co Page 1. 1 Respuesta de los pacientes con Leucemia Mieloide Crónica al
tratamiento con Imatinib Ana Libia Moreno García Trabajo ... Related articles
- ►aacrjournals.org E Laurent, M Talpaz, H Kantarjian, R Kurzrock - Cancer Research, 2001 - AACR Recent investigations have rapidly added crucial new insights into the complex
functions of the normal BCR gene and of the BCR-ABL chimera and are yielding
potential therapeutic breakthroughs in the treatment of Philadelphia (Ph) ... Cited by 71 - Related articles - BL Direct - All 3 versions
FJ Giles, JE Cortes, HM Kantarjian, SM O' … - Hematology/oncology clinics of North America, 2004 - Elsevier Chronic myelogenous leukemia (CML) traditionally has been characterized by a
biphasic or triphasic course [1 and 2]. Eighty-five to 90% of patients are
diagnosed in the chronic phase (CP), which is asymptomatic in up to 25% of ... Cited by 22 - Related articles - BL Direct - All 3 versions
DJ Barnes, JV Melo - Acta Haematologica, 2000 - content.karger.com Chronic myeloid leukaemia (CML) is caused by the product of the BCR-ABL
oncogene, located on the Philadelphia (Ph) chromosome. BCR-ABL is generated as a
result of a reciprocal t(9;22) chromosomal translocation. The mechanisms ... Cited by 54 - Related articles - BL Direct - All 7 versions
DJ Barnes, JV Melo, 2000 - content.karger.com Karger is a medical publisher, scientific publisher and biomedical
publisher of print and online journals and books.
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E Laurent, DL Mitchell, Z Estrov, M Lowery, … - Clinical Cancer Research, 2003 - AACR Recently, it was shown that both Bcr and Bcr-Abl can interact with xeroderma
pigmentosum group B (XPB/ERCC3), a protein implicated in DNA repair after
UV-induced damage. To further analyze the effect of Bcr-Abl on the DNA ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►pitt.edu [PDF] MB Wilson, 2004 - etd.library.pitt.edu Page 1. THE ROLE OF SRC FAMILY TYROSINE KINASES IN BCR-ABL SIGNAL TRANSDUCTION
AND CHRONIC MYELOGENOUS LEUKEMIA by Matthew Brian Wilson ... Related articles - View as HTML - All 4 versions
AB Raitano, YE Whang, CL Sawyers - BBA-Reviews on Cancer, 1997 - Elsevier The cloning of chromosome translocation breakpoints in human leukemias has
identified a number of oncogenic fusion proteins. Bcr–Abl was the first such
fusion gene identified and is found in 95% of patients with chronic ... Cited by 86 - Related articles - All 4 versions
- ►haematologica-thj.org [PDF] A Sureda, M Carrasco, M De Miguel, JA … - Haematologica, 2003 - haematologica.org Background and Objectives. Imatinib mesylate (STI571) is a selective inhibitor
of the bcr/abl tyrosine kinase with therapeutic potential in the blast crisis
(BC) of chronic myel- ogenous leukemia (CML). Design and Methods. We report ... Cited by 33 - Related articles - BL Direct - All 15 versions
