- ►annals.org DT Chen, FG Miller, DL Rosenstein - Annals of internal medicine, 2003 - Am Coll Physicians All practicing physicians should be prepared to respond to requests from patients for advice about
participating in clinical trials research. Even physicians who choose not to conduct clinical trials
but rather devote their practice to clinical care may have patients who consider ... Cited by 34 - Related articles - All 4 versions
DT Chen, BB Worrall - Seminars in neurology, 2006 - ncbi.nlm.nih.gov Due to the growth and expansion of clinical research, particularly research conducted in
practice-based settings, all practicing physicians should have a fundamental understanding
of clinical research and the differences between clinical care and clinical research. ... Cited by 8 - Related articles - BL Direct - All 5 versions
DT Chen, BB Worrall - Seminars in Neurology, 2006 - thieme-connect.com Calls for increasing clinical research in routine care settings aim to improve the empirical and
ethical foundations of evidence-based practice. In the treatment and prevention of stroke many
troubling management questions remain uninvestigated by the clinical research ... Cited by 5 - Related articles - BL Direct - All 6 versions
- ►jhu.edu [PDF] H Brody, FG Miller - Kennedy Institute of Ethics Journal, 2003 - muse.jhu.edu Abstract The "difference position" holds that clinical research and therapeutic medical practice
are sufficiently distinct activities to require different ethical rules and principles. The "similarity
position" holds instead that clinical investigators ought to be bound by the same ... Cited by 36 - Related articles - BL Direct - All 6 versions
R Steinbrook - New England Journal of Medicine, 2005 - content.nejm.org E ven as they have advanced our understanding and treatment of disease, the achievements
of modern biomedical research have also increased people's ability to misuse discoveries in
ways that could threaten the public health or national security. The phrase “dual-use ... Cited by 3 - Related articles - BL Direct - All 4 versions
JE Beach - Accountability in research, 2001 - ncbi.nlm.nih.gov When contract research organizations (CROs) were first formed, pharmaceutical companies
outsourced to them only certain aspects of the conduct of their clinical trials. At first CROs were
highly specialized entities, providing, for example, either biostatistical advice, clinical ... Cited by 5 - Related articles - All 2 versions
JE Klein, AR Fleischman - The Hastings Center Report, 2002 - questia.com Incentives to physicians for patient recruitment and retention are not new. In academic medical
centers, physician-investigators have for years accrued substantial secondary gain, for either
themselves or their departments, by conducting clinical trials. Income from clinical trials ... Cited by 21 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org EW Lader, CP Cannon, EM Ohman, LK Newby, DP … - Circulation, 2004 - Am Heart Assoc The rapid development of new drugs, therapies, and devices has created a dramatic increase
in the number of trials needed to properly evaluate them. The majority of patients treated
today, many of whom could be eligible for participation in these studies, are seen in ... Cited by 22 - Related articles - BL Direct - All 11 versions
FG Miller, DL Rosenstein, EG DeRenzo - JAMA, 1998 - Am Med Assoc In response to public concern over abuses in human medical experimentation, the dominant
approach to the ethics of clinical research during the past 30 years has been regulation, particularly
via institutional review board review and approval of scientific protocols and written ... Cited by 111 - Related articles - BL Direct - All 3 versions
