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Scholar Results 1 - 10 of about 101 related to Padayatty: Vitamin C pharmacokinetics: implications for oral and intravenous use. (0.09 sec) 

Vitamin C pharmacokinetics: implications for oral and intravenous use

- ivvitaminsnj.us [PDF] 
SJ Padayatty, H Sun, Y Wang, HD Riordan, SM … - Annals of internal medicine, 2004 - Am Coll Physicians
From the National Institute of Diabetes and Digestive and Kidney Diseases, the
National Cancer Institute, and the Clinical Center, National Institutes of
Health, Bethesda, Maryland; the Food and Drug Administration, Rockville, ...
Cited by 106 - Related articles - BL Direct - All 21 versions

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro- …

- nih.gov
Q Chen, MG Espey, MC Krishna, JB Mitchell, … - Proceedings of the National Academy of Sciences of …, 2005 - National Acad Sciences
Human pharmacokinetics data indicate that iv ascorbic acid (ascorbate) in
pharmacologic concentrations could have an unanticipated role in cancer
treatment. Our goals here were to test whether ascorbate killed cancer ...
Cited by 112 - Related articles - BL Direct - All 40 versions

Intravenously administered vitamin C as cancer therapy: three cases

- ecmaj.ca
SJ Padayatty, HD Riordan, SM Hewitt, A Katz, … - Canadian Medical Association Journal, 2006 - Can Med Assoc
Early clinical studies showed that high-dose vitamin C, given by intravenous and
oral routes, may improve symptoms and prolong life in patients with terminal
cancer. Double-blind placebo-controlled studies of oral vitamin C therapy ...
Cited by 35 - Related articles - BL Direct - All 41 versions

[PDF] Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours


JJ Casciari, NH Riordan, TL Schmidt, XL … - British journal of cancer, 2001 - bcrionline.org
Vitamin C (ascorbic acid, ascorbate) is a major water soluble antioxidant with a
variety of biological functions. It plays roles in collagen and carnitine
synthesis and may be important in main- taining proper immune cell function ...
Cited by 45 - Related articles - BL Direct - All 5 versions

Orthomolecular oncology review: ascorbic acid and cancer 25 years later

- ivvitaminsnj.us [PDF] 
MJ González, JR Miranda-Massari, EM Mora, … - Integr Cancer Ther, 2005 - ict.sagepub.com
The effect of ascorbic acid on cancer has been a subject of great controversy.
This is a follow-up review of the 1979 arti- cle by Cameron, Pauling, and
Leibovitz published in Cancer Research. In this updated version, the ...
Cited by 30 - Related articles - All 11 versions

High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who …


CG Moertel, TR Fleming, ET Creagan, J … - New England Journal of Medicine, 1985 - content.nejm.org
It has been claimed that high-dose vitamin C is beneficial in the treatment of
patients with advanced cancer, especially patients who have had no prior
chemotherapy. In a double-blind study 100 patients with advanced colorectal ...
Cited by 206 - Related articles - All 6 versions

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and …

- nih.gov
Q Chen, MG Espey, AY Sun, JH Lee, MC … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences
Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily
achieved in humans by iv administration, selectively kills some cancer cells but
not normal cells. We proposed that pharmacologic ascorbate is a prodrug for ...
Cited by 37 - Related articles - BL Direct - All 12 versions

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive …

- nih.gov
Q Chen, MG Espey, AY Sun, C Pooput, KL Kirk … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences
Ascorbic acid is an essential nutrient commonly regarded as an antioxidant. In
this study, we showed that ascorbate at pharmacologic concentrations was a
prooxidant, generating hydrogen-peroxide-dependent cytotoxicity toward a ...
Cited by 34 - Related articles - All 10 versions

Reevaluation of ascorbate in cancer treatment: emerging evidence, open minds and …


SJ Padayatty, M Levine - Journal of the American College of Nutrition, 2000 - Am Coll Nutrition
Lack of vitamin C results in scurvy. Daily intake of 100 milligrams of vitamin C
will prevent scurvy for one month if further ingestion ceases. However, optimum
requirements of vitamin C for good health are unknown. This has led to wild ...
Cited by 23 - Related articles - BL Direct - All 5 versions

[PDF] Vitamin C Pharmacokinetics: Implications for Oral and bo3 Intravenous Use


P Studies, H Persons - Ann Intern Med, 2004 - bcrionline.org
~ebastian 1. Padayatty, MRCP, PhD; He Sun, PhD, CBS; Yaohui Wang, MD; Hugh D.
Riordan, MD; Stephen M. Hewitt, MD, PhD; Arie Katz, MD; Robert A. Wesley, PhD;
and Mark Levine, MD ... Background: Vitamin C at high concentrations is ...
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