- ►annals.org [PDF] HA Ghofrani, F Reichenberger, MG Kohstall, … - Annals of internal medicine, 2004 - Am Coll Physicians Background: Alveolar hypoxia causes pulmonary hypertension and enhanced right
ventricular afterload, which may impair exer- cise tolerance. The
phosphodiesterase-5 inhibitor sildenafil has been reported to cause ... Cited by 122 - Related articles - BL Direct - All 10 versions
- ►atsjournals.org JP Richalet, P Gratadour, P Robach, I Pham, M … - American journal of respiratory and critical care …, 2005 - Am Thoracic Soc Exposure to high altitude induces pulmonary hypertension that may lead to
life-threatening conditions. In a randomized, double-blind, placebo-controlled
study, the effects of oral sildenafil on altitude-induced pulmonary ... Cited by 105 - Related articles - All 7 versions
AA Aldashev, BK Kojonazarov, TA Amatov, TM … - British Medical Journal, 2005 - thorax.bmj.com Results: At 3 months, patients on sildenafil 25 mg 8 hourly (n = 9) had a
significantly (p = 0.018) lower mean PAP (–6.9 mm Hg) at the end of the dosing
interval than those on placebo (n = 8) (95% CI –12.4 to –1.3). The ... Cited by 56 - Related articles - BL Direct - All 10 versions
- ►physiology.org AR Hsu, KE Barnholt, NK Grundmann, JH Lin, … - Journal of Applied Physiology, 2006 - Am Physiological Soc Sildenafil causes pulmonary vasodilation, thus potentially reducing impairments
of hypoxia-induced pulmonary hypertension on exercise performance at altitude.
The purpose of this study was to determine the effects of sildenafil during ... Cited by 31 - Related articles - BL Direct - All 7 versions
- ►161.116.7.34 [PDF] A Ricart, J Maristany, N Fort, C Leal, T Pagés, … - High Altitude Medicine & Biology, 2005 - liebertonline.com Page 1. INTRODUCTION S EA - LEVEL DWELLERS EXPOSED TO altitude hy- poxia
exhibit pulmonary vasoconstriction and a secondary increase ... Cited by 21 - Related articles - All 4 versions
- ►atsjournals.org RT Schermuly, KP Kreisselmeier, HA Ghofrani … - American journal of respiratory and critical care …, 2004 - Am Thoracic Soc Sildenafil, a phosphodiesterase 5 inhibitor, is currently under investigation
for therapy of pulmonary hypertension. This study was designed to investigate
chronic effects of sildenafil in monocrotaline (MCT)-induced pulmonary ... Cited by 110 - Related articles - All 8 versions
- ►onlinejacc.org E Grünig, D Mereles, W Hildebrandt, ER … - Journal of the American College of Cardiology, 2000 - Elsevier This work was presented in part at the 70th Scientific Sessions of the American
Heart Association, Orlando, FL, 1997, and was supported by a grant from the
University of Heidelberg. ... This prospective single-blinded study was ... Cited by 96 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org L Zhao, NA Mason, NW Morrell, B Kojonazarov … - Circulation, 2001 - Am Heart Assoc Methods and Results— In a randomized, double-blind study, sildenafil 100 mg or
placebo was given orally to 10 healthy volunteers 1 hour before breathing 11% O
2 for 30 minutes. Pulmonary artery pressure (PAP) was measured with an ... Cited by 337 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org M Maggiorini, C Melot, S Pierre, F Pfeiffer, I … - Circulation, 2001 - Am Heart Assoc Methods and Results—We studied pulmonary hemodynamics, including capillary
pressure determined by the occlusion method, and capillary permeability
evaluated by the pulmonary transvascular escape of 67 Ga-labeled ... Cited by 161 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org A Sebkhi, JW Strange, SC Phillips, J Wharton … - Circulation, 2003 - Am Heart Assoc Methods and Results— Sprague-Dawley rats were exposed to hypoxia (10% O 2 )
for up to 42 days. PAP, measured continuously by telemetry, increased gradually
by 20 to 40 mm Hg, reaching a plateau between 10 and 14 days, and declined ... Cited by 134 - Related articles - BL Direct - All 6 versions
