- ►annals.org [PDF] DM Roden, RB Altman, NL Benowitz, DA … - Annals of internal medicine, 2006 - Am Coll Physicians The outcome of drug therapy is often unpredictable, ranging from beneficial
effects to lack of efficacy to serious adverse effects. Variations in single
genes are 1 well-recognized cause of such unpredictability, defining the ... Cited by 85 - Related articles - BL Direct - All 3 versions
MUVD RESPONSES - Ann Intern Med, 2006 - courses.ahc.umn.edu The outcome of drug therapy is often unpredictable, ranging from beneficial
effects to lack of efficacy to serious adverse effects. Variations in single
genes are 1 well-recognized cause of such unpredictability, defining the ... Related articles - View as HTML - All 3 versions
JJ Swen, TW Huizinga, H Gelderblom, EG de … - PLoS Med, 2007 - medicine.plosjournals.org Pharmacogenomics is one of the first clinical applications of the postgenomic
era. It promises personalized medicine rather than the established “one size
fits all” approach to drugs and dosages. The expected reduction in trial ... Cited by 36 - Related articles - Cached - All 12 versions
RM Weinshilboum, L Wang, 2006 - Annual Reviews Abstract Pharmacogenetics and pharmacogenomics involve the study of the role of
inheritance in individual variation in drug response, a phenotype that varies
from potentially life-threatening adverse drug reactions to equally serious ... Cited by 42 - Related articles - All 3 versions
SJ Gardiner, EJ Begg - Pharmacological reviews, 2006 - ASPET The application of pharmacogenetics holds great promise for individualized
therapy. However, it has little clinical reality at present, despite many
claims. The main problem is that the evidence base supporting genetic ... Cited by 71 - Related articles - BL Direct - All 6 versions
- ►umb.edu [PDF] CEI Szoeke, M Newton, JM Wood, D Goldstein, … - Lancet Neurology, 2006 - Elsevier Recent developments in the pharmacogenetics of antiepileptic drugs provide new
prospects for predicting the efficacy of treatment and potential side-effects.
Epilepsy is a common, serious, and treatable neurological disorder, yet ... Cited by 24 - Related articles - All 13 versions
- ►royalsocietypublishing.org RR Shah - Philosophical Transactions B, 2005 - rstb.royalsocietypublishing.org Pharmacogenetic factors operate at pharmacokinetic as well as pharmacodynamic
levels—the two components of the dose–response curve of a drug.
Polymorphisms in drug metabolizing enzymes, transporters and/or ... Cited by 34 - Related articles - BL Direct - All 11 versions
CC Hung, CJ Lin, CC Chen, CJ Chang, HH … - Therapeutic drug monitoring, 2004 - journals.lww.com Abstract: To search for the optimal dosage of phenytoin in patients with
epilepsy based on the metabolic activities of CYP2C9 and CYP2C19 polymorphisms,
a total of 169 patients receiving phenytoin treatment for more than 1 month ... Cited by 36 - Related articles - BL Direct - All 3 versions
MM Hopkins, D Ibarreta, S Gaisser, CM Enzing … - Nature biotechnology, 2006 - york.ac.uk Pharmacogenetics, the study of variation in patient responses to drugs due to
heredi- tary traits, has been suggested as the area of genetics with the most
potential to rapidly provide public health benefits1. Although early ... Cited by 39 - Related articles - View as HTML - BL Direct - All 6 versions
T Hampton - JAMA, 2005 - Am Med Assoc Such was the finding by David Goldstein, PhD, and colleagues at the University
College London, in England, who discovered that particular genetic variations
could explain variation in response of patients with epilepsy to ... Cited by 4 - Related articles - All 4 versions
