- ►angrylapdog.com PS Mueller, VM Montori, D Bassler, … - Annals of Internal …, 2007 - annals.org.p.angrylapdog.com Stopping randomized trials early because of an apparent benefit is becoming more common. To protect
and promote the interests of trial participants, investigators may feel obligated to stop a trial
early because of the apparent ... Cited by 34 - Related articles - BL Direct - All 3 versions
S Validity - Ann Intern Med, 2007 - bioethicsforum.info Stopping randomized trials early because of an apparent benefit is becoming more common. To protect
and promote the interests of trial participants, investigators may feel obligated to stop a trial
early because of the apparent ... Related articles - View as HTML
RA Wilcox, B Djulbegovic, GH Guyatt, VM … - Journal of Clinical …, 2008 - jcojournal.org Investigators conducting randomized controlled trials (RCTs) who find a large treatment effect
before the planned completion of the study may terminate the study early. A systematic review of
RCTs that were stopped early for ... Cited by 13 - Related articles - All 4 versions
- ►ceb-institute.org [PDF] D Bassler, VM Montori, M Briel, P Glasziou, G … - Journal of Clinical …, 2008 - Elsevier The best strategy to minimize the problems associated with early stopping of RCTs for benefit is not
to stop early. As an alternative, we suggest a threefold approach: a low P-value as the threshold
for stopping at the time of interim ... Cited by 24 - Related articles - All 13 versions
B Freidlin, EL Korn - Clinical Trials, 2009 - ctj.sagepub.com Background It has been suggested in the literature that the well-known bias of treatment-effect
estimators due to the possibility of early stopping for positive results is a major concern with
interim monitoring. Purpose To ... Cited by 4 - Related articles - All 2 versions
- ►annals.org SN Goodman - Annals of Internal Medicine, 2007 - Am Coll Physicians This commentary reviews the argument that clinical trials with data monitoring committees that use
statistical stopping guidelines should generally not be stopped early for large observed efficacy
differences because efficacy ... Cited by 20 - Related articles - BL Direct - All 3 versions
XF Fan, DL DeMets, KK Lan - Journal of biopharmaceutical statistics, 2004 - ncbi.nlm.nih.gov Repeated significance testing in a sequential experiment not only increases the overall type I error
rate of the false positive conclusion but also causes biases in estimating the unknown parameter. In
general, the test statistics in a ... Cited by 8 - Related articles - BL Direct - All 3 versions
- ►ceb-institute.org [PDF] D Bassler, I Ferreira-Gonzalez, M Briel, DJ Cook, … - Journal of Clinical …, 2007 - Elsevier We searched the Cochrane Library and MEDLINE and evaluated systematic reviews that include at least
one tRCT. We documented approaches that authors used to address potential overestimates of treatment
effect introduced by including ... Cited by 18 - Related articles - All 10 versions
K Wheatley, D Clayton - Controlled clinical trials, 2003 - Elsevier The preliminary results of the twelfth Medical Research Council acute myeloid leukemia trial show no
evidence of a survival advantage for five courses of therapy compared to four courses in a
randomized comparison involving ... Cited by 60 - Related articles - All 7 versions
- ►bnir.org [PDF] SJ Pocock - Jama, 2005 - Am Med Assoc Second, with or without a formal DMC recommendation, another question is whether the decision to
stop a trial early and report the results was an appropriate judgment. This decision should be aided
by a predefined statistical ... Cited by 52 - Related articles - BL Direct - All 3 versions
