RL CAPIZZI, JR Bertino, RT Skeel, WA … - Annals of Internal Medicine, 1971 - Am Coll Physicians Forty patients with acute leukemia were treated with Intravenous L-asparaginase
in doses ranging from 10 to 1,000 international units/kg body weight per day for
2 to 20 days. Most had long-standing disease and had exhausted conventional ... Cited by 92 - Related articles - All 2 versions
HF Oettgen, PA Stephenson, MK Schwartz, RD … - CA A Cancer Journal for Clinicians - interscience.wiley.com During therapeutic trials with E. coli L-asparaginase in 131 children and 143
adults with neoplastic disease the following signs of toxicity have been
observed: fever, nausea and vomiting, weight loss, somnolence, lethargy, ... Cited by 153 - Related articles - All 2 versions
- ►nih.gov [PDF] RG Peterson, RE Handschumacher, MS … - Journal of Clinical Investigation, 1971 - pubmedcentral.nih.gov A BSTRACT In a series of 40 patients treated with L-asparaginase for various
neoplastic diseases, 6 patients had generalized anaphylactic reactionsto
L-asparaginase. Each of these reactors had antibodies detectable by pas- ... Cited by 41 - Related articles - All 5 versions
CM Haskell, GP Canellos, BG Leventhal, PP … - The New England journal of medicine, 1969 - ncbi.nlm.nih.gov 1: N Engl J Med. 1969 Nov 6;281(19):1028-34. L-asparaginase: therapeutic
and toxic effects in patients with neoplastic disease. ... Cited by 146 - Related articles
D Killander, A Dohlwitz, L Engstedt, S … - CA A Cancer Journal for Clinicians - interscience.wiley.com One hundred and fourteen patients with acute leukemia, 57 children (10 AML and
47 ALL) and 57 adults (37 AML and 20 ALL) were treated with L-asparaginase
(Asnase) 200 or 1000 IU/kg daily for 30 days unless withdrawn on account of ... Cited by 51 - Related articles - All 2 versions
B Clarkson, I Krakoff, J Burchenal, D … - CA A Cancer Journal for Clinicians - interscience.wiley.com E. coli L-asparaginase (A-ase) was administered to 163 adults with different
forms of leukemia, lymphoma, and solid tumors. Six of 11 patients with acute
lymphoblastic leukemia and 4 of 32 patients with acute myeloblastic, ... Cited by 73 - Related articles - All 2 versions
RL Capizzi, JR Bertino, RE Handschumacher - Annual Review of Medicine, 1970 - Annual Reviews RL CAPIZZI,2 MD, J. R. BERTINO,2 MD, AND RE HANDSCHUMACHER,2 MD Departments of
Medicine and Pharmacology, Yale University School of Medicine, New Haven,
Connecticut INTRODUCTION Investigators have long sought to discover an ... Cited by 98 - Related articles - All 3 versions
DH Ho, NS Brown, A Yen, R Holmes, M … - Drug Metabolism and Disposition, 1986 - ASPET Page 1. Send reprint requests to: Dr. Dah Hsi Ho, Department of Chemotherapy Research,
Box 52, MD Anderson Hospital, 6723 Bertner Avenue, Houston, TX 77030. 349 ... Cited by 74 - Related articles - All 3 versions
L Tallal, C Tan, H Oettgen, N Wollner, M … - CA A Cancer Journal for Clinicians - interscience.wiley.com One hundred thirty-one children between 1 and 15 years of age have been treated.
Ninety-five children had acute lymphoblastic leukemia (ALL); 13 had other types
of leukemia; 8 had lymphoma; and 15 had other solid tumors. The dosage ... Cited by 90 - Related articles - All 2 versions
JR Priest, NKC Ramsay, AJ Bennett, W Krivit, … - The Journal of Pediatrics, 1982 - Elsevier Hemostatic function was studied sequentially in 12 children receiving
l-asparaginase, vincristine, and prednisone as remission induction chemotherapy
for acute lymphoblastic leukemia. The three-week period of l-asparaginase ... Cited by 78 - Related articles - All 3 versions
