HJ SHULL Jr, GR WILKINSON, R JOHNSON … - Annals of Internal Medicine, 1976 - Am Coll Physicians Oxazepam (Serax®) is a tranquilizer-sedative of the benzodiazepine group that
is predominantly metabolized to a pharmacologically inactive glucuronide and
subsequently excreted by way of the kidneys. We administered this drug as a ... Cited by 169 - Related articles - All 2 versions
RK Roberts, GR Wilkinson, RA Branch, S … - Gastroenterology, 1978 - ncbi.nlm.nih.gov There is an increased incidence of unwanted sedation associated with
chlordiazepoxide usage in the elderly and in patients with liver disease. To
determine whether pharmacokinetic alterations could account in part for ... Cited by 102 - Related articles - All 3 versions
- ►nih.gov [PDF] U Klotz, GR Avant, A Hoyumpa, S Schenker, … - Journal of Clinical Investigation, 1975 - pubmedcentral.nih.gov A BSTRACT This studyinvestigates the separate ef- fects of age and
hepatocellular liver disease on the disposition and elimination of diazepam
(Valium) in man. The drug was given either byrapid intravenous injection ... Cited by 425 - Related articles - All 6 versions
RI Shader, DJ Greenblatt, JS Harmatz, K … - Journal of clinical pharmacology - ncbi.nlm.nih.gov 1: J Clin Pharmacol. 1977 Nov-Dec;17(11-12):709-18. Absorption and disposition
of chlordiazepoxide in young and elderly male volunteers. ... Cited by 65 - Related articles - All 2 versions
RV Patwardhan, RF Johnson, A Hoyumpa Jr, … - Gastroenterology, 1981 - ncbi.nlm.nih.gov Morphine disposition and elimination was studied in 6 healthy male subject s and
6 male patients with cirrhosis, to assess the role of differences, if any, on
the reported intolerance of morphine in cirrhosis. In addition the ... Cited by 123 - Related articles - All 2 versions
EM Sellers, DJ Greenblatt, HG Giles, CA … - Clinical pharmacology and therapeutics, 1979 - ncbi.nlm.nih.gov When disease impairs clearance of drugs, multiple-dose therapy may result in
cumulation. The disposition of chlordiazepoxide (CDX), 50 mg infused
intravenously over 10 min, was studied in 14 normal subjects and in 11 ... Cited by 30 - Related articles
MD Allen, DJ Greenblatt, JS Harmatz, RI … - Clinical Pharmacology & Therapeutics, 1980 - nature.com Our subjects were 15 young (aged 22 to 42 yr) and 14 elderly (aged 62 to 85 yr)
people who took single oral doses of 20 mg prazepam. Plasma desmethyldiazepam
(DMDZ) concentrations were determined in venous blood samples drawn up to 9 ... Cited by 62 - Related articles - All 2 versions
