GP WORMSER, GT KEUSCH - Annals of Internal Medicine, 1979 - Am Coll Physicians After approximately 5 years of clinical use in Great Britain and other European countries,
trimethoprim-sulfamethoxazole in fixed-dose combination was introduced into the United States
in 1973. As a result of sequential blockade in the biosynthesis of tetrahydrofolic acid, the ... Cited by 49 - Related articles - All 2 versions
R Gleckman, S Alvarez, DW Joubert - American Journal of Health- …, 1979 - ajhp.highwire.org The mechanism of action, antimicrobial spectrum, pharmacokinetic properties, drug
interactions, adverse reactions and therapeutic uses of trimethoprim-sulfamethoxazole, a combination
enzyme-specific inhibitor of bacterial folate synthesis, are reviewed. Trimethoprim- ... Cited by 15 - Related articles - All 4 versions
JM Frisch - The Journal of Infectious Diseases, 1973 - jstor.org Close monitoring of adverse reactions to the trimethoprim-sulfamethoxazole combination reported
over four years since marketing, during which more than 25 million standard 20-tablet courses
have been administered, shows the pattern and relative incidence of adverse reactions ... Cited by 47 - Related articles - All 2 versions
BT Nguyen, S Stadtsbaeder - Pathologia Europaea, 1975 - ncbi.nlm.nih.gov Cotrimoxazole, from 60 mug/ml, inhibited the replication of Toxoplasma gondii within Hela cells
and mouse peritoneal macrophages. The percentage of inhibition reached practically 100%
after 18 hours of treatment at 37 degrees C. More prolonged treatment resulted in an ... Cited by 12 - Related articles
JD Smilack - Mayo Clinic Proceedings, 1999 - mayoclinicproceedings.com After 25 years of use in the United States, trimethoprim-sulfamethoxazole (TMP-SMX) is widely
prescribed for various indications. By virtue of sequential blockade of microbial folic acid
synthesis, the antimicrobial combination has excellent in vitro inhibitory activity against ... Cited by 35 - Related articles - BL Direct - All 8 versions
EM Opremcak, DK Scales, MR Sharpe - Ophthalmology, 1992 - ncbi.nlm.nih.gov BACKGROUND: Toxoplasmosis is a leading cause of retinochoroiditis. Conventional multidrug
therapy using sulfadiazine, pyrimethamine, and folinic acid is increasingly difficult to procure
and administer safely. METHODS: To evaluate the efficacy of ... Cited by 21 - Related articles - All 3 versions
- ►nih.gov [PDF] CL Hall - British Medical Journal, 1974 - bmj.com Page 1. doi:10.1136/bmj.4.5935.15 1974;4;15-16 Br Med J CL Hall Combination
Co-trimoxazole and Azathioprine: A Safe These include: Rapid responses
http://bmj.com/cgi/eletter-submit/4/5935/15 You can respond to this article at: ... Cited by 4 - Related articles - All 4 versions
RH Rubin, MN Swartz - New England Journal of Medicine, 1980 - content.nejm.org Original Article from The New England Journal of Medicine -- Trimethoprim-sulfamethoxazole.
Cited by 64 - Related articles - All 2 versions
AL Tulloch - The Journal of Pediatrics, 1976 - Elsevier PEDIATRIC PHARMACOLOGY AND THERAPEUTICS Paul S. Lietman, Editor Pancytopenia
in an infant associated with sulfamethoxazole-trimethoprim therapy Pancytopenia in a
seven-month-old babyis described and attributed to sulfamethoxazole-trimethoprim ... Cited by 8 - Related articles - All 2 versions
