RP DANIELE, JH DAUBER, MD … - Annals of Internal …, 1980 - Am Coll Physicians Patients with active sarcoidosis (acute and chronic) have a depression in systemic cell-mediated
immunity manifested by a reduction in the number of circulating T cells and impaired responses
of these cells to polyclonal mitogens and recall antigens. These abnormalities are absent ... Cited by 158 - Related articles - All 2 versions
- ►nih.gov [PDF] GW Hunninghake, RG Crystal - Journal of Clinical Investigation, 1981 - pubmedcentral.nih.gov A B STR A CT Pulmonary sarcoidosis is a disorder in which local granuloma formation is perpetuated
by acti- vated lung T lymphocytes. The present study suggests that lung T lymphocytes may also
play a critical role in modulating local production of antibodies in this dis- order. In ... Cited by 87 - Related articles - All 4 versions
GW Hunninghake, JE Gadek, RC Young, O … - New England Journal …, 1980 - content.nejm.org Pulmonary granulomata of sarcoidosis are composed primarily of mononuclear phagocytic cells
that are probably derived from blood monocytes. To evaluate the concept that recruitment of
blood monocytes to the sarcoid lung is mediated by chemoattractants produced by ... Cited by 134 - Related articles - All 2 versions
GW Hunninghake, JD Fulmer, RC Young Jr, … - The American review of …, 1979 - ncbi.nlm.nih.gov Pulmonary sarcoidosis is an interstitial disease characterized by granulomas within the lung
parenchyma, anergy to a variety of skin tests, and decreased numbers of circulating
T-lymphocytes. To evaluate the effector cell populations present at sites of disease in ... Cited by 95 - Related articles
… , JE GADEK, JD FULMER, BR LINE - Annals of Internal …, 1981 - Am Coll Physicians The alveolitis of pulmonary sarcoidosis is characterized by an intense, mononuclear cell infiltrate
that probably precedes granuloma formation. Pathogenic mechanisms underlying pulmonary
sarcoidosis can be shown by study of the mononuclear cells composing the alveolitis. ... Cited by 208 - Related articles
P Pinkston, PB Bitterman, RG Crystal - New England Journal of …, 1983 - content.nejm.org We investigated the possible role of interleukin-2, a T-cell product that stimulates the clonal increase
of responsive T lymphocytes, in the pathogenesis of pulmonary sarcoidosis. We obtained mononuclear
effector cells from the lungs of 10 patients with sarcoidosis and high-intensity alveolitis, 17 ... Cited by 224 - Related articles - All 5 versions
GW Hunninghake, RG Crystal - New England Journal of Medicine, 1981 - content.nejm.org Using the monoclonal antibodies OKT4 and OKT8, we determined the proportions of helper and
suppressor T cells in patients with sarcoidosis and high-intensity alveolitis, patients with sarcoidosis
and low-intensity alveolitis, patients with idiopathic pulmonary fibrosis (IPF), and normal ... Cited by 471 - Related articles - All 2 versions
GW Hunninghake, GN Bedell, DC Zavala, M … - The American review of …, 1983 - ncbi.nlm.nih.gov Using a human T-cell line sensitive to interleukin-2 (IL-2), we evaluated supernatants of
unstimulated, purified lung T-lymphocytes from patients with sarcoidosis and high-intensity alveolitis
(active disease), patients with sarcoidosis and low-intensity alveolitis (inactive disease), ... Cited by 94 - Related articles - All 2 versions
JS GOODWIN, R DeHORATIUS, H ISRAEL, … - Annals of Internal …, 1979 - Am Coll Physicians We investigated the role of suppressor cells in the depressed cellular immunity of patients with
sarcoidosis. The mean response in 16 patients with active sarcoidosis to three concentrations
of phytohemagglutinin was significantly (P < 0.01) less than control values. Passage of ... Cited by 73 - Related articles - All 3 versions
RP DANIELE, DT ROWLANDS Jr - Annals of Internal Medicine, 1976 - Am Coll Physicians We studied lymphocytes from the peripheral blood of 29 sarcoid patients to relate T- and B-cell
populations with disease activity and duration. In patients with acute (< 1 year) and chronic (
9 years) active disease, the absolute lymphocyte count was reduced; the absolute ... Cited by 45 - Related articles - All 3 versions
