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Scholar Results 1 - 10 of about 101 related to Howell: Intraperitoneal cis-diamminedichloroplatinum with systemic thiosulfate protection. (0.10 sec) 

Intraperitoneal cis-diamminedichloroplatinum with systemic thiosulfate protection

- aacrjournals.org [PDF] 
SB Howell, CE Pfeifle, WE Wung, RA Olshen - Cancer Research, 1983 - AACR
The toxicity and pharmacokinetics of c/s-diamminedichloro- platinum (cisplatin) (90 mg/sq m)
administered as a single 4- hr peritoneal dialysis, with or without concurrent iv infusion of sodium
thiosulfate, 0.43 or 2.13 g/sq m/hr ...
Cited by 431 - Related articles - All 7 versions

Pharmacokinetic rationale for peritoneal drug administration in the treatment of …


RL Dedrick, CE Myers, PM Bungay, VT DeVita … - Cancer treatment …, 1978 - ncbi.nlm.nih.gov
Evidence from the peritoneal dialysis literature suggests that the peritoneal permeability of a
number of hydrophilic anticancer drugs may be considerably less than plasma clearance.
Pharmacokinetic calculations ...
Cited by 468 - Related articles

Ip cisplatin in patients with malignant ascites: pharmacokinetic evaluation and …


ES Casper, DP Kelsen, NW Alcock, JL Lewis … - Cancer treatment reports, 1983 - ncbi.nlm.nih.gov
Ip chemotherapy may be useful in managing patients with malignant ascites. This approach should
result in a high concentration of drug at the site of disease, while the plasma concentration and
therefore systemic toxicity remain ...
Cited by 117 - Related articles

Phase I and pharmacological studies of adriamycin administered intraperitoneally …

- aacrjournals.org [PDF] 
RF Ozols, RC Young, JL Speyer, PH Sugarbaker, R … - Cancer Research, 1982 - AACR
A Phase I study of Adriamycin administered ip was per formed in 10 ovarian cancer patients who were
refractory to systemic chemotherapy. Adriamycin was infused in 2 liters of Inpersol via a
semipermanent Tenckhoff dialysis ...
Cited by 173 - Related articles - All 3 versions

Phase I and pharmacological studies of 5-fluorouracil administered …

- aacrjournals.org [PDF] 
JL Speyer, JM Collins, RL Dedrick, MF Brennan, AR … - Cancer Research, 1980 - AACR
MATERIALS AND METHODS Ten patients from the Medicine and Surgery Branches of the National Cancer
Institute were treated (Table i ). All patients had histological proof of malignant disease confined
to the intraabdominal space. All ...
Cited by 187 - Related articles - All 2 versions

Effect of sodium thiosulfate on cis-dichlorodiammineplatinum (II) toxicity and …


SB Howell, R Taetle - Cancer treatment reports - ncbi.nlm.nih.gov
Concurrent administration of sodium thiosulfate reduced the toxicity of
cis-dichlorodiammineplatinum(II) (DDP) in a dose-related manner in mice. Sodium thiosulfate
protected mice against an otherwise ...
Cited by 130 - Related articles

Long-term survival of advanced refractory ovarian carcinoma patients with small- …

- jcojournal.org [PDF] 
SB Howell, S Zimm, M Markman, IS Abramson, … - Journal of Clinical …, 1987 - jcojournal.org
Long-Term Survival of Advanced Refractory Ovarian Carcinoma Patients With Small-Volume Disease
Treated With Intraperitoneal Chemotherapy ... By Stephen B. Howell, Solomon Zimm, Maurie Markman,
lan S. Abramson, Steven Cleary, ...
Cited by 154 - Related articles - All 7 versions

High-volume intraperitoneal chemotherapy with methotrexate in patients with …

- aacrjournals.org [PDF] 
RB Jones, JM Collins, CE Myers, AE Brooks, SM … - Cancer Research, 1981 - AACR
The use of high-volume ip chemotherapy with methotrexate (7.5 to 50 P.Mmethotrexate administered via
peritoneal dialysis technique) was studied in four patients with ovarian cancer and one patient with
malignant melanoma. All had tumor ...
Cited by 82 - Related articles - All 4 versions

Pharmacokinetics of Ip cisplatin in refractory ovarian carcinoma.


RG Pretorius, NF Hacker, JS Berek, LC Ford, JD … - Cancer treatment …, 1983 - ncbi.nlm.nih.gov
Four patients with small residual ovarian carcinoma following treatment with cisplatin, doxorubicin,
and cyclophosphamide have subsequently received 57 courses of ip cisplatin. Cisplatin (120-270 mg in
2 L of Ringer's lactate) was ...
Cited by 64 - Related articles

Pharmacokinetics of adriamycin and tissue penetration in murine ovarian cancer

- aacrjournals.org [PDF] 
RF Ozols, GY Locker, JH Doroshow, KR Grotzinger, CE … - Cancer Research, 1979 - AACR
Robert F. Ozols,1 Gershon Y. Locker, James H. Doroshow, Karen R. Grotzinger, Charles E. Myers, and
Robert C. Young ... Medicine (RF 0., KAG, RCV] and Clinical Pharmacology (GVL, JHD, CEMj Branches,
Division of Cancer Treatment ...
Cited by 168 - Related articles - All 2 versions


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