HB BREWER Jr, LA ZECH, RE GREGG, D … - Annals of internal …, 1983 - Am Coll Physicians Type III hyperlipoproteinemia is characterized by increased plasma levels of triglycerides and
cholesterol, palmar-tuberoeruptive xanthoma, and premature cardiovascular disease. Three
major classes of molecular defects will predispose patients to develop type III ... Cited by 153 - Related articles - All 3 versions
J MORGANROTH, RI LEVY, DS … - Annals of Internal …, 1975 - Am Coll Physicians The clinical and biochemical features of type III hyperlipoproteinemia are described in 49 patients
from 23 to 70 years of age. An increase in very low-density lipoproteins (VLDL) of abnormal chemical
composition was the basis for diagnosis. The untreated patients all had ... Cited by 160 - Related articles - All 3 versions
G Utermann, KH Vogelberg, A Steinmetz, W … - Clinical genetics, 1979 - ncbi.nlm.nih.gov Apolipoprotein E from human serum shows a genetic polymorphism determined by two autosomal
codominant alleles, Apo En and Apo Ed. Homozygosity for the gene Apo Ed (phenotype Apo
ED) results in primary dysbetalipoproteinemia, but only some individuals with this ... Cited by 130 - Related articles
RE Gregg, LA Zech, EJ Schaefer, HB Brewer Jr - Science, 1981 - sciencemag.org Patients with type III hyperlipopro- teinemia (HLP) have increased plasma concentrations of triglyceride
and cho- lesterol and a ratio of very low density lipoprotein (VLDL) cholesterol to total plasma
triglyceride of more than 0.3. Other characteristics of this disease, which is also known as ... Cited by 112 - Related articles - All 5 versions
G Feussner, A Wagner, B Kohl, R Ziegler - Journal of Molecular Medicine, 1993 - Springer Summary. The clinical and biochemical character- istics of type III hyperlipoproteinemia are
de- scribed in 64 patients (35 males and 29 females). Homozygosity for apolipoprotein E2, the
presence of an abnormally cholesterol-rich very low density lipoprotein fraction (/%VLDL) ... Cited by 21 - Related articles - All 3 versions
RJ Havel - The Medical clinics of North America, 1982 - ncbi.nlm.nih.gov New aspects in the pathogenesis and diagnosis of familial dysbetalipoproteinemia are
discussed, including the clarification of the chemical basis of the polymorphism of apoprotein
E, the allelic nature of the primary isoforms of the protein, the relationship of the ... Cited by 97 - Related articles
- ►nih.gov [PDF] P De Knijff, AM Van den Maagdenberg, … - Journal of Clinical …, 1991 - pubmedcentral.nih.gov Abstract By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands
showing heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies re- vealed
that these probands share common ancestry in the 17th century. In a group of 128 family ... Cited by 80 - Related articles - All 5 versions
L Havekes, E Wit, JG Leuven, E Klasen, W Utermann, … - Human genetics, 1986 - Springer Summary. A variant of apolipoprotein E, denoted apo E3- Leiden, has been identified in a
41-year-old male suffering from type III hyperlipoproteinemia with xanthomatosis. Apo E3-Leiden
focus in the E3 position. In contrast with normal apo E3, apo E3-Leiden is defective in ... Cited by 67 - Related articles - All 3 versions
KH Weisgraber, TL Innerarity, RW Mahley - J Biol Chem, 1982 - ASBMB THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 257, No. 5, Issue of March 10, pp.
2518-2521, 1982 Printed in U. SA ... Abnormal Lipoprotein Receptor-binding Activity of the Human
E Apoprotein due to Cysteine-Arginine Interchange at a Single Site* Cited by 401 - Related articles - All 3 versions
- ►nih.gov [PDF] EJ Schaefer, RE Gregg, G Ghiselli, TM … - Journal of Clinical …, 1986 - pubmedcentral.nih.gov A unique kindred with premature cardiovascular disease, tubo- eruptive xanthomas, and type
III hyperlipoproteinemia (HLP) associated with familial apolipoprotein (apo) E deficiency was
examined. Homozygotes (n = 4) had marked increases in cho- lesterol-rich very low ... Cited by 190 - Related articles - All 9 versions
