GA PORTER - Annals of internal medicine, 1983 - Am Coll Physicians The observations that have provided the foundation of the sodium hypothesis of human hypertension
are reviewed. Clinical observations made over 125 years ago initiated an investigative effort
that has encompassed epidemiologic data, development of salt-related experimental ... Cited by 16 - Related articles - All 2 versions
JC HUNT - Annals of Internal Medicine, 1983 - Am Coll Physicians Cardiovascular disease is the leading cause of death worldwide. Hypertension—the leading
cause of heart attack, stroke, and kidney failure—occurs in more than 20% of adults in most modern
societies. Hypertensive patients have defective sodium metabolism. From childhood ... Cited by 16 - Related articles - All 2 versions
L TOBIAN - Annals of internal medicine, 1983 - Am Coll Physicians Hypertension has been linked to dietary sodium intake in humans. It is possible that 9% to
20% of the population may be genetically susceptible to developing essential hypertension by
middle life. The remainder of the population may be genetically resistant to developing ... Cited by 20 - Related articles - All 2 versions
SM FRIEDMAN - Annals of Internal Medicine, 1983 - Am Coll Physicians Steep transmembrane concentration gradients in vascular smooth muscle for all ions are maintained
by energy-requiring pumps. The Na + gradient appears to dominate the distribution of the other
ions primarily because it controls cell hydration and energizes the transport of sugars, ... Cited by 8 - Related articles - All 2 versions
JH LARAGH, MS PECKER - Annals of internal medicine, 1983 - Am Coll Physicians Rigorous sodium deprivation can lower the blood pressure of some patients with essential hypertension
(at best, 30% to 50% of patients). In the rest, sodium depletion is ineffective and, in some
instances, can raise the blood pressure and cause adverse clinical effects. In normal ... Cited by 63 - Related articles - All 2 versions
[CITATION] duV., S. Uppal, and C. Clowy. 1976. Relation between blood pressure, weight, and …
