AR Feinstein - Annals of internal medicine, 1983 - Am Coll Physicians Although highly successful in investigating remedial therapy, randomized clinical trials have
sometimes created rather than clarified controversy when the treatments were given for the complex
problems involved in studying either the primary prevention of disease or the secondary ... Cited by 209 - Related articles - All 3 versions
AR FEINSTEIN - Annals of internal medicine, 1983 - Am Coll Physicians The main scientific virtue of randomized allocation of treatment is an unpredictability that reduces
susceptibility bias in the groups created when treatments are assigned preferentially according
to prognostic differences. Even in randomized trials, however, prognostic analyses are ... Cited by 70 - Related articles - All 4 versions
AR Feinstein - Annals of Internal Medicine, 1983 - Am Coll Physicians The four main conceptual paradigms of basic biomedical research are that the explication of
mechanisms is a primary goal of science; that scientific data must be "hard"; that formulation
of hypotheses and counter-hypotheses is a principal creative challenge; and that ... Cited by 84 - Related articles - All 2 versions
AR FEINSTEIN - Annals of internal medicine, 1983 - Am Coll Physicians The domain of clinimetrics is concerned with quantitative methods in the collection and analysis
of comparative clinical data, and particularly with improved "measurement" of the distinctively
clinical and personal phenomena of patient care. The main requirement for scientific ... Cited by 137 - Related articles - All 3 versions
T Pincus - Journal of clinical epidemiology, 1988 - ncbi.nlm.nih.gov 1: J Clin Epidemiol. 1988;41(11):1037-41. Rheumatoid arthritis: disappointing long-term
outcomes despite successful short-term clinical trials. Pincus T. Department of Medicine,
Vanderbilt University School of Medicine, Nashville, TN 37232. ... Cited by 108 - Related articles - All 2 versions
T Pincus, CM Stein - Clinical and experimental rheumatology - ncbi.nlm.nih.gov The randomized controlled clinical trial is the "gold standard" to evaluate therapeutic
interventions, but is more effectively applied to studies of the short-term treatment of acute diseases
than to the long-term treatment of chronic diseases. Clinical observations often provide ... Cited by 58 - Related articles - BL Direct - All 2 versions
[CITATION] Limitations of randomized controlled clinical trials to recognize possible …
GA Diamond, JS Forrester - Annals of Internal Medicine, 1983 - Am Coll Physicians Conventional interpretation of clinical trials relies heavily on the classic p value. The p value,
however, represents only a false-positive rate, and does not tell the probability that the investigator's
hypothesis is correct, given his observations. This more relevant posterior probability can ... Cited by 92 - Related articles - All 2 versions
RI Horwitz, BH Singer, RW Makuch, CM Viscoli - Journal of Clinical …, 1996 - Elsevier Randomized controlled trials are conducted with heterogeneous groups of patients, and the
trial results represent an estimate of the average difference in the responses of the treatment
groups. Clinicians, however, engage in a process of clinical inquiry, assembling data that ... Cited by 70 - Related articles - BL Direct - All 4 versions
