- ►annals.org [PDF] TE Warkentin, JG Kelton - Annals of Internal Medicine, 2001 - Am Coll Physicians Background: Heparin-induced thrombocytopenia is a prothrom- botic drug reaction caused by
platelet-activating antibodies that recognize complexes of platelet factor 4 and heparin.
Objective: To describe a syndrome termed delayed-onset hepa- rin-induced ... Cited by 227 - Related articles - BL Direct - All 7 versions
L Rice, WK Attisha, JL Francis - Annals of Internal Medicine, 2003 - Am Coll Physicians TO THE EDITOR: There are 2 forms of heparin-induced thrombo- cytopenia. Type 1 is common
and trivial. The incidence of heparin- induced thrombocytopenia type 2, which causes serious
thrombosis in patients receiving full doses of heparin for therapy (not for hip replacement ... Cited by 195 - Related articles - BL Direct - All 6 versions
- ►stanford.edu [PDF] TE Warkentin, JG Kelton - New England Journal of Medicine, 2001 - content.nejm.org ABSTRACT Background Heparin-induced thrombocytopenia is a relatively common
antibody-mediated drug reaction. We studied the temporal relation between previous or current
heparin therapy and the onset of heparin- induced thrombocytopenia. Methods We ... Cited by 447 - Related articles - BL Direct - All 13 versions
N Lubenow, R Kempf, A Eichner, P Eichler, LE … - Chest, 2002 - ncbi.nlm.nih.gov STUDY OBJECTIVES: Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse
drug reaction associated with a decrease of platelet counts that usually begins after at least 5
days of heparin treatment. Uncertainty exists about the risk of early onset of HIT (ie, < 5 ... Cited by 130 - Related articles - BL Direct - All 2 versions
- ►bloodjournal.org TE Warkentin, JAI Sheppard, P Horsewood, PJ … - Blood, 2000 - Am Soc Hematology Two general types of laboratory assay are used to confirm the diagnosis. Activation assays, such
as the platelet serotonin release assay, detect HIT-IgG on the basis of their ability to activate
platelets. 11-13 Antigen assays, such as a solid-phase immunoassay, detect the binding ... Cited by 333 - Related articles - BL Direct - All 7 versions
TE Warkentin, JG Kelton - The American journal of medicine, 1996 - Elsevier Heparin-induced thrombocytopenia was associated with the development of new venous thrombotic
events and arterial thrombotic events in 78 and 18 patients, respectively (ratio venous/arterial
thrombosis = 4:1). Pulmonary embolism was the most common life-threatening thrombotic ... Cited by 492 - Related articles - BL Direct - All 6 versions
TE Warkentin - Archives of Pathology and Laboratory Medicine, 2002 - arpa.allenpress.com Archives of Pathology and Laboratory Medicine: Vol. 126, No. 11, pp. 1415–1423. ...
Objective.—Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug
reaction that paradoxically is associated with a brief but dramatically increased risk for ... Cited by 135 - Related articles - BL Direct - All 4 versions
- ►bloodjournal.org A Greinacher, P Eichler, N Lubenow, H Kwasny, M Luz - Blood, 2000 - Am Soc Hematology Thrombin plays a central role in HIT-related thromboembolic complication (TEC). Thrombin generation
is enhanced in HIT by the concomitant activation of platelets, 10 the generation of platelet
microparticles, 11 and the alteration of endothelial cells. 5 Immediate cessation of heparin ... Cited by 255 - Related articles - BL Direct - All 6 versions
DE Wallis, DL Workman, BE Lewis, L Steen, R … - The American journal of …, 1999 - Elsevier RESULTS: Of the 113 patients, 38% developed thrombosis and 27% died. One-half of patients
had thrombosis diagnosed >24 hours after heparin cessation. No difference in thrombosis or
mortality was found in the 40 patients with early heparin cessation [mean (±SD) time of ... Cited by 237 - Related articles - BL Direct - All 6 versions
- ►osu.edu [PDF] TE Warkentin, RS Roberts, J Hirsh, JG … - Archives of Internal …, 2003 - archinte.highwire.org Background Diagnosis of immune heparin-induced thrombocytopenia (HIT) is usually based
on a fall in platelet count below 150 x 10 9 /L (standard definition of thrombocytopenia).
However, this definition may be inappropriate for postoperative patients who often ... Cited by 169 - Related articles - BL Direct - All 6 versions
