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“Did This Drug Cause My Patient's Hepatitis?” and Related Questions


P Questions, P Internist - Annals of Internal Medicine - Am Coll Physicians
W hat should the busy internist do when his or her patient, while taking several
medications, suddenly develops a new clinical problem, such as hepatitis? Is the
acute hepatitis drug related? If so, which drug is to blame? The case ...
Related articles

[CITATION] Troglitazone-associated hepatotoxicity treated successfully with steroids


KA Prendergast, CL Berg, R Wisniewski - Annals of Internal Medicine, 2000 - Am Coll Physicians
Letters commenting on an Annals article will be considered if they are received
within 6 weeks of the time the article was published. Only some of the letters
received can be published. Published letters are edited and may be ...
Cited by 8 - Related articles - BL Direct - All 3 versions

Case Report: Severe but Reversible Hepatitis Induced by Troglitazone


T Schiano, K Dolehide, J Hart, AL Baker - Digestive diseases and sciences, 2000 - Springer
Troglitazone (Rezulin), a recently introduced oral antidiabetic drug of the
thiazolidinedione class, is ordinarily prescribed along with sulfonylureas or
in- sulin to improve blood sugar control. Troglitazone and other ...
Cited by 9 - Related articles - BL Direct - All 5 versions

Introduction to clinical pharmacology and rational therapeutics


D Nieremberg, K Melmon - Melmon and Morrelli's Clinical Pharmacology: Basic …, 2000 - books.google.com
INTRODUCTION TO CLINICAL PHARMACOLOGY AND RATIONAL THERAPEUTICS David W.
Nierenberg, Kenneth L. Melmon Chapter Outline HISTORICAL PERSPECTIVE ON CURRENT
PROBLEMS WITH THERAPEUTICS AN APPROACH TO RATIONAL THERAPEUTICS AN OVERVIEW ...
Cited by 3 - Related articles - All 2 versions

Hepatotoxicity of thiazolidinediones


WL Isley - eds, 2003 - informahealthcare.com
Thiazolidinediones are insulin sensitisers now widely used for the treatment of
Type 2 diabetes mellitus. The initial marketed drug in this class, troglitazone,
was removed from the market worldwide after approximately 3 years of use ...
Cited by 53 - Related articles - BL Direct - All 9 versions

Troglitazone-induced fulminant hepatitis Report of a case with autopsy findings


H Li, DS Heller, CB Leevy, KG Zierer, KM … - Journal of diabetes and its complications, 2000 - Elsevier
A 71-year-old man with type 2 diabetes was treated with troglitazone for 10
months. He had been initially treated by his private physician. He was started
on oral troglitazone, 200 mg daily in August of 1998. Laboratory studies ...
Cited by 11 - Related articles - BL Direct - All 10 versions

Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy

- annals.org [PDF] 
LD May, JH Lefkowitch, MT Kram, DE Rubin - Annals of internal medicine, 2002 - Am Coll Physicians
Louis D. May, MD; Jay H. Lefkowitch, MD; Michael T. Kram, MD; and David E.
Rubin, MD ... Background: Pioglitazone is an oral hypoglycemic agent in the
thiazolidinedione class. Only one case of hepatotoxicity related to this ...
Cited by 86 - Related articles - All 6 versions

[CITATION] Rapid-onset subfulminant liver failure associated with troglitazone.


S Jagannath, R Rai - Annals of internal medicine, 2000 - ncbi.nlm.nih.gov
1: Ann Intern Med. 2000 Apr 18;132(8):677. Comment on: Ann Intern Med. 1998
Jul 1;129(1):36-8. Ann Intern Med. 1998 Jul 1;129(1):38-41. ...
Cited by 12 - Related articles - BL Direct

Second-generation thiazolidinediones and hepatotoxicity


TR Marcy, ML Britton, SM Blevins - The Annals of pharmacotherapy, 2004 - Harvey Whitney Books
CASE SUMMARY: A 39-year-old black woman with type 2 diabetes mellitus,
hypertension, and congestive heart failure presented to a pharmacist-staffed
diabetes comanagement service. She reported fatigue, dark brown urine, ...
Cited by 43 - Related articles - All 5 versions

Risk of adverse events with concomitant use of atorvastatin or simvastatin and glucose- …


AA Alsheikh-Ali, HM Abourjaily, RH Karas - The American journal of cardiology, 2002 - Elsevier
A database describing all reports of adverse drug reactions from November 1997
to April 2000, in which either of the 2 most widely prescribed statins,
simvastatin or atorvastatin, were listed as the primary or secondary causal ...
Cited by 17 - Related articles - All 5 versions


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