DA Ausiello, DJ Benos, F Abboud, W Koopman … - Ann Intern Med, 2004 - Am Coll Physicians Few diagnoses in medicine are more dispiriting for pa- tients and their families
than Alzheimer disease. This insidious dissolution of one's most human
qualities—rea- soning, abstraction, language, and memory—now affects ... Cited by 152 - Related articles - All 14 versions
DJ Selkoe - Clinical Neuroscience Research, 2001 - Elsevier Progressive cerebral deposition of the 40- and 42-residue amyloid β-proteins is
an early and invariant event in all forms of Alzheimer's disease (AD). Aβ
proteins are generated from the β-amyloid precursor protein (APP) via two ... Cited by 12 - Related articles - All 6 versions
DJ Selkoe - Neurologic clinics, 2000 - 万方数据资源系统 The study of Alzheimer's disease (AD) has had more than its share of
controversy. In the last few years, however, considerable consensus has been
developed that certain molecular events in the brain occur many years or ... Cited by 92 - Related articles - BL Direct - All 6 versions
- ►umb.edu [PDF] DJ Selkoe, MB Podlisny - Annual Review of Genomics and Human Genetics, 2002 - Annual Reviews ▪ Abstract A remarkable rise in life expectancy during the past century has
made Alzheimer's disease (AD) the most common form of progressive cognitive
failure in humans. Compositional analyses of the classical brain lesions, ... Cited by 134 - Related articles - All 7 versions
- ►physiology.org DJ Selkoe - Physiological reviews, 2001 - Am Physiological Soc Selkoe, Dennis J. Alzheimer's Disease: Genes, Proteins, and Therapy. Physiol.
Rev. 81: 741-766, 2001. Rapid progress in deciphering the biological mechanism
of Alzheimer's disease (AD) has arisen from the application of molecular ... Cited by 2274 - Related articles - BL Direct - All 21 versions
DJ Selkoe - Nature cell biology, 2004 - yorku.ca A blurring of the traditional distinction between basic and applied research is
increasingly evident in the study of neurodegeneration. Complex and previously
enigmatic diseases of post-mitotic neurons, such as Parkinson's, ... Cited by 207 - Related articles - BL Direct - All 9 versions
M Morishima-Kawashima, Y Ihara - Journal of Neuroscience Research, 2002 - interscience.wiley.com Research on the molecular pathogenesis of Alzheimer's disease (AD) has made
great strides over the last decade. This progress is the result of protein
chemical analysis of two extracellular and intracellular fibrillary lesions ... Cited by 36 - Related articles - BL Direct - All 3 versions
S Sinha - Medical Clinics of North America, 2002 - Elsevier Alzheimer's disease (AD) is characterized, upon postmortem analyses of the
brain, by the presence of two major pathologic lesions, the senile or neuritic
plaque, and neurofibrillary tangles, both identified by Alois Alzheimer in ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►nih.gov DJ Selkoe - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Progressive dysfunction of neurons in the limbic and association cortices
underlies the cognitive failure of AD. This cellular dysfunction is preceded by
the accumulation of extracellular aggregates of the 42-residue amyloid β- ... Cited by 146 - Related articles - BL Direct - All 6 versions
