RA Brodsky, P Principles - Annals of Internal Medicine, 2008 - Am Coll Physicians Y ou are asked to see a 37-year-old male carpenter who was noted to be anemic and mildly
thrombocytopenic during a routine physical examination. The patient has been married for 11
years and has a 5-year-old son and an 8-year-old daughter. He reports that he has been ... Cited by 13 - Related articles - BL Direct - All 13 versions
- ►hematologylibrary.org RA Brodsky - Blood, 2009 - bloodjournal.hematologylibrary.org Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal blood disorder that manifests with
hemolytic anemia, bone marrow failure, and thrombosis. Many of the clinical manifestations of
the disease result from complement-mediated intravascular hemolysis. Allogeneic bone ... Cited by 3 - Related articles
J Schubert, P Hillmen, A Roth, N Young, M … - British Journal of …, 2008 - interscience.wiley.com In paroxysmal nocturnal haemoglobinuria (PNH), chronic destruction of PNH red blood cells
(RBCs) by complement leads to anaemia and other serious morbidities. Eculizumab inhibits
terminal complement-mediated PNH RBC destruction by targeting C5. In the phase III, ... Cited by 6 - Related articles - All 3 versions
RA Brodsky - Blood reviews, 2008 - Elsevier PNH is an uncommon acquired hemolytic anemia that often manifests with hemoglobinuria, abdominal
pain, smooth muscle dystonias, fatigue, and thrombosis. The disease results from the expansion
of hematopoietic stem cells harboring a mutation in a gene, PIG-A, that is required for the ... Cited by 9 - Related articles - All 12 versions
[CITATION] The investigation of HMGA2 dysregulation and promoter mutations in PIG-M in the …
RA Brodsky, P Hillmen, J Schubert, L … - ASCO Meeting …, 2007 - meeting.ascopubs.org Background: Myelodysplastic syndrome (MDS) and aplastic anemia (AA) have been reported
to be associated with the development of the acquired clonal hemolytic and bone marrow failure
disorder, paroxysmal nocturnal hemoglobinuria (PNH). Two recent phase 3 clinical ... Cited by 2 - Related articles - All 2 versions
GL Mukhina, JT Buckley, JP Barber, RJ … - British journal of …, 2001 - ingentaconnect.com Page 1. 476 q 2001 Blackwell Science Ltd Multilineage glycosylphosphatidylinositol
anchor-deficient haematopoiesis in untreated aplastic anaemia Galina L. Mukhina, 1 J. Thomas
Buckley 2 James P. Barber, 1 Richard J. Jones 1 and Robert A. Brodsky 1 ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►alphamedpress.org A Traulsen, JM Pacheco, D Dingli - Stem Cells, 2007 - AlphaMed Press The pool of hematopoietic stem cells that actively contributes to hematopoiesis is small, and
the cells replicate slowly. Patients with paroxysmal nocturnal hemoglobinuria invariably have
a mutation in the PIG-A gene, and many have more than one clone of PIG-A mutated ... Cited by 11 - Related articles - BL Direct - All 5 versions
- ►hematologylibrary.org RA Brodsky, NS Young, E Antonioli, AM … - …, 2008 - bloodjournal.hematologylibrary.org The terminal complement inhibitor eculizumab was recently shown to be effective and well tolerated
in patients with paroxysmal nocturnal hemoglobinuria (PNH). Here, we extended these observations
with results from an open-label, non–placebo-controlled, 52-week, phase 3 clinical safety ... Cited by 55 - Related articles - BL Direct - All 3 versions
