pnas.org[PDF] JG Herman, JR Graff, S Myöhänen, … - Proceedings of the …, 1996 - National Acad Sciences Page 1. Proc. Natl. Acad. Sci. USA Vol. 93, pp. 9821-9826, September 1996 Medical
Sciences Methylation-specific PCR: A novel PCR assay for methylation status of CpG
islands (DNA methylation/tumor suppressor genes/pl6/p15) ... Cited by 3659 - Related articles - BL Direct - All 13 versions
aacrjournals.org[HTML] M Esteller, PG Corn, SB Baylin, JG Herman - Cancer Research, 2001 - AACR We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations
characterizing each form of human cancer. Such profiles would provide invaluable insight into
mechanisms underlying the evolution of each tumor type and will provide molecular ... Cited by 1281 - Related articles - BL Direct - All 5 versions
SB Baylin, JG Herman, JR Graff, PM … - Advances in cancer …, 1998 - ncbi.nlm.nih.gov Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more regional
areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) activity. Each
component of this "methylation imbalance" may fundamentally contribute to tumor ... Cited by 1443 - Related articles - BL Direct - All 5 versions
pnas.org[PDF] M Frommer, LE McDonald, DS Millar, … - Proceedings of the …, 1992 - National Acad Sciences Page 1. Proc. Nati. Acad. Sci. USA Vol. 89, pp. 1827-1831, March 1992 Genetics A genomic
sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA
strands (genomic sequencing/DNA methylation/bisulfite modiflication/PCR/kininogen ... Cited by 1324 - Related articles - All 11 versions
ucsb.edu[PDF] PA Jones, PW Laird… - Nature genetics, 1999 - chem.ucsb.edu The appearance and behaviour of cells are determined by the genes expressed in that cell. The
abnormal behaviour of cancer cells can thus be explained by invoking quantitative and/or
quali- tative changes in this active gene set. Sequence-based qualitative changes have ... Cited by 1537 - Related articles - View as HTML - BL Direct - All 10 versions
A Merlo, JG Herman, L Mao, DJ Lee, E Gabrielson, … - Nature Medicine, 1995 - nature.com Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified
in human cancer. The rate of point mutations of p16, a candidate suppressor gene of this
area, is low in most primary tumours with allelic loss of 9p21. Monosomic cell lines with ... Cited by 1321 - Related articles - All 2 versions
nih.gov[PDF] Z Xiong, PW Laird - Nucleic acids research, 1997 - Oxford Univ Press We report here on a quantitative technique called COBRA to determine DNA methylation levels
at specific gene loci in small amounts of genomic DNA. Restriction enzyme digestion is used
to reveal methylation- dependent sequence differences in PCR products of sodium ... Cited by 650 - Related articles - BL Direct - All 7 versions
ucsb.edu[PDF] PA Jones, SB Baylin - Nature Reviews Genetics, 2002 - chem.ucsb.edu In the mammalian genome, methylation takes place only at cytosine bases that are located
5′ to a guanosine in a CpG dinucleotide1. This dinucleotide is actually under- represented
in much of the genome, but short regions of 0.5–4 kb in length, known as CpG islands, ... Cited by 2131 - Related articles - View as HTML - BL Direct - All 15 versions
pnas.org[HTML] JG Herman, A Umar, K Polyak, JR … - Proceedings of the …, 1998 - National Acad Sciences Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability
(MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island of hMLH1 is
found in the majority of sporadic primary colorectal cancers with MSI, and that this ... Cited by 1148 - Related articles - BL Direct - All 9 versions
aacrjournals.org[PDF] JG Herman, A Merlo, LI Mao, RG Lapidus, JPJ Issa, NE … - Cancer research, 1995 - AACR David Sidransky, and Stephen B. Baylin The Oncology Center (JGH, RG L, fP. .1. I., NED,
DS, SBB], Department of Medicine (SBBJ, Baltimore. Maryland 21231, and Department of
Otolarvngologv. The Johns Hopkins University School ofMedicine. Baltimore, Maryland ... Cited by 978 - Related articles - BL Direct - All 3 versions
