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Despite the multi-systemic nature of Behçet’s disease (BD), renal involvement is rare in this disease1. However, various involvements including amyloidosis2, focal and diffuse proliferative glomerulonephritis (with or without sclerosis) 3, crescentic glomerulonephritis3, and IgA nephropathy4 have been reported in association with BD. As with other manifestations of the disease, prevalence varies widely due to ethnic variations or environmental factors1. The aim of this study was to investigate the prevalence and characteristics of urine abnormalities and renal involvement of BD in Iran, and their effects on disease expression.