Authors
Anwar Fathollahi, Saeed Aslani, Ahmadreza Jamshidi, Mahdi Mahmoudi
Publication date
2019/8
Source
Journal of cellular physiology
Volume
234
Issue
8
Pages
12309-12324
Description
Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an absolute consequence of joint mechanical use (wear and tear); rather recent data demonstrate the pivotal role of inflammatory mediators in the development and progression of this disease. This multifactorial disease results from several environmental and inherited factors. Genetic cannot solely explain all the contribution share of inheritance and, this way, it is speculated that epigenetics can play a role, too. Moreover, environmental factors can induce local epigenetic changes. The epigenetic contribution to OA pathogenesis occurs at all of its levels, DNA methylation, histone modification, microRNA, and long noncoding RNA. In fact, during early phases of OA pathogenesis, environmental factors employ epigenetic mechanisms to provide a positive feedback for the OA‐related pathogenic mechanisms and pathways with an …
Total citations
201920202021202220232024871612122
Scholar articles
A Fathollahi, S Aslani, A Jamshidi, M Mahmoudi - Journal of cellular physiology, 2019