Authors
E Farhadi, S Nemati, AA Amirzargar, A Hirbod-Mobarakeh, M Nabavi, S Soltani, SA Mahdaviani, S Shahinpour, S Arshi, B Nikbin, A Aghamohammadi, Nima Rezaei
Publication date
2014/9/1
Journal
Allergologia et immunopathologia
Volume
42
Issue
5
Pages
422-426
Publisher
No longer published by Elsevier
Description
Background
Primary antibody deficiencies (PADs) are a heterogeneous group of disorders, characterised by increased susceptibility to recurrent bacterial infections. Common variable immunodeficiency (CVID) is the most important PAD from the clinical point of view and selective IgA deficiency (IgAD) is the most common PAD. However, the underlying gene defect in both is still unknown. As a recent study in Europe showed an association between a single nucleotide polymorphism (SNP) of AICDA gene with PADs, this study was performed to evaluate such an association in Iranian patients.
Methods
Fifty-eight patients with PAD, including 39 CVID and 19 IgAD, as well as 34 healthy volunteers, were enrolled in this study. Genotyping was done in all groups for an intronic SNP in AICDA (rs2580874), using real-time PCR genotyping assay.
Results
The less frequent genotype of AICDA in IgAD patients was AA, seen in …
Scholar articles
E Farhadi, S Nemati, AA Amirzargar… - Allergologia et immunopathologia, 2014