Authors
Nasser Ebrahimi Daryani, Maryam Sadr, Shirin Moossavi, Sepideh Shahkarami, Samaneh Soltani, Elham Farhadi, Nima Rezaei
Publication date
2015/5
Journal
Digestive Diseases and Sciences
Volume
60
Pages
1389-1395
Publisher
Springer US
Description
Background and Aim
Interleukin (IL)-1 family members play an important role in the pathogenesis of inflammatory bowel disease (IBD). There are conflicting results regarding the association of IL-1 gene cluster single nucleotide polymorphisms (SNPs) with IBD and its clinical features. The aim of this study was to examine IL- −889 C/T, IL- −511 C/T, IL- +3962 C/T, IL-1R Pst-I1970 C/T, and IL-1RA Mspa-I11100 C/T SNPs in Iranian patients.
Methods
In this study, SNPs of IL-1 family members were investigated in 75 patients with IBD (40 CD and 35 UC), using polymerase chain reaction with sequence-specific primers method.
Results
IL- −511 CC genotype was significantly less present in UC compared to controls, while IL-1RA Mspa-I11100 CC was significantly associated with both Crohn’s disease …
Total citations
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Scholar articles
NE Daryani, M Sadr, S Moossavi, S Shahkarami… - Digestive Diseases and Sciences, 2015