Authors
M Sadrossadat, Ebrahimi N Daryani, SH Moossavi, S Shahkarami, S Soltani, E Farhadi, N Rezaei
Publication date
2014/10/1
Journal
Iranian Journal of Pediatrics
Volume
24
Issue
S2
Pages
S33
Publisher
Tehran University of Medical Sciences
Description
Background: Crohn's disease (CD) and ulcerative colitis (UC) are two inflammatory bowel diseases (IBD) in which host-microbiota dysbiosis is expected in a genetically susceptible host. There are conflicting results on role of single nucleotide polymorphisms (SNPs) in IL-1 family members in IBD.
Methods: In this study, SNPs of IL-1 family were investigated in 74 patients with IBD (40 CD and 35 UC), using PCR-SSP method.
Findings: IL-1β-511 CC genotype was significantly less present in UC compared to controls, while IL-1RA-Mspa-I11100 CC was significantly associated with both CD and UC. IL-1α-889 TT genotype was more frequently associated with extraintestinal manifestations. A significant association was observed between IL-1β+ 3962 TT genotype and the disease activity in IBD. IL-1RA Mspa-I11100 CC significantly less frequent in CD patients who need immunosuppressive therapy. IL-1RA Mspa …
Scholar articles
M Sadrossadat, EN Daryani, SH Moossavi… - Iranian Journal of Pediatrics, 2014