Authors
N Behniafard, AA Amirzargar, M Gharagozlou, F Delavari, S Hosseinverdi, S Sotoudeh, E Farhadi, M Mahmoudi, M Khaledi, Z Gholizadeh Moghaddam, A Aghamohammadi, Nima Rezaei
Publication date
2018/3/1
Journal
Allergologia et Immunopathologia
Volume
46
Issue
2
Pages
155-159
Publisher
No longer published by Elsevier
Description
Background
Atopic dermatitis is an inflammatory skin disease in which both genetic and environmental factors interact to determine the susceptibility and severity of the disease.
Objective
The aim of this study was to determine the association between atopic dermatitis and IL-10 and TGF-β1 gene polymorphisms.
Methods
The allele and genotype frequencies of genes encoding for IL-10 and TGF-β1 were investigated in 89 patients with atopic dermatitis in comparison with 138 in the control group using the PCR-SSP method.
Results
A significant increase was found in the frequency of the TGF-β1 codon 10/C allele among patients (p < 0.001, OR = 6.77), whereas a significant decrease was observed in the frequency of the T allele at the same position (p < 0.001, OR = 0.14). The frequency of the TGF-β1 codon 25/G allele in the control group was significantly higher than among patients (p < 0.001, OR = 0.08). A significant …
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Scholar articles
N Behniafard, AA Amirzargar, M Gharagozlou… - Allergologia et Immunopathologia, 2018