Authors
Mona Hedayat, Mohammad Jafar Mahmoudi, Mohammad Taghvaei, Ebrahim Nematipour, Elham Farhadi, Nilufar Esfahanian, Maryam Mahmoudi, Maryam Sadr, Keramat Nourijelyani, Ali Akbar Amirzargar, Nima Rezaei
Publication date
2018/4
Journal
Avicenna Journal of Medical Biotechnology
Volume
10
Issue
2
Pages
105
Publisher
Avicenna Research Institute
Description
Background:
Proinflammatory cytokines have been known to be elevated in patients with Chronic Heart Failure (CHF). Given the importance of proinflammatory cytokines in the context of the failing heart, the prevalence of Tumor Necrosis Factor-α (TNF-α), Interleukin (IL)-6 polymorphisms in patients with CHF was studied due to ischemic heart disease.
Methods:
Forty three patients with ischemic heart failure were enrolled in this study and compared with 140 healthy individuals. The allele and genotype frequency of four Single Nucleotide Polymorphisms (SNPs) within the IL-6 (-174, nt565) and TNF-α (-308,-238) genes were determined, using Polymerase Chain Reaction with Sequence-Specific Primers (PCR-SSP) assay.
Results:
The frequency of the TNF-α (-238) A/A genotype was significantly higher in patients comparing to controls (p= 0.043), while TNF-α G/A genotype at the same position decreased significantly …
Total citations
Scholar articles
M Hedayat, MJ Mahmoudi, M Taghvaei, E Nematipour… - Avicenna Journal of Medical Biotechnology, 2018