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Methods

The study was performed on 67 Iranian adult patients with UC and 78 healthy controls. Eight IL23R SNPs were genotyped, using real-time polymerase chain reaction (RT-PCR). The frequencies of alleles and genotype at each position were determined and compared between two groups of patients and controls.

Results

The frequency of the T allele at position rs1343151 was significantly higher in the patient group, compared to the controls (P= 0.018). The TT genotype at the same position was also significantly overrepresented in the patient group (P= 0.02). There was no significant difference in alleles and genotype frequencies of other SNPs between patients and controls.

Conclusions

This study identified a new susceptibility locus associated with UC. Our findings provide further insight into the genetics of UC, which might be amenable to future therapeutic intervention.