Authors
R Nasiri, A Hirbod-Mobarakeh, M Movahedi, E Farhadi, B Ansaripour, AA Amirzargar, Nima Rezaei
Publication date
2016/3/1
Journal
Allergologia et Immunopathologia
Volume
44
Issue
2
Pages
125-130
Publisher
No longer published by Elsevier
Description
Background
Allergic rhinitis (AR) is a polygenic inflammatory disorder of the upper respiratory airway with an increasing prevalence worldwide. Interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β), as two cytokines with pleiotropic effects on both innate and adaptive immunity, play important roles in allergic responses. Therefore, this study was performed to evaluate the associations of five polymorphisms of IL-10 and TGF-β genes with AR.
Materials and methods
Ninety-eight patients with AR along with 140 healthy volunteers with no history of AR and with the same ethnicity of the patients were recruited in this study. Genotyping was done for three polymorphisms in promoter region of IL-10 gene (rs1800896, rs1800871, rs1800872), and two polymorphisms in the exonic region of TGF-β1 gene (rs1982037, rs1800471) using PCR sequence-specific-primers method.
Results
A allele and AA genotype in …
Scholar articles
R Nasiri, A Hirbod-Mobarakeh, M Movahedi, E Farhadi… - Allergologia et Immunopathologia, 2016