Authors
Nima Rezaei, Zahra Aryan, Nasrin Behniafard, Elham Farhadi, Soheila Sotoudeh, Mojdeh Khaledi, Maryam Mahmoudi, Asghar Aghamohammadi, Ali Akbar Amirzargar, Mohammad Gharagozlou
Publication date
2014/2/1
Journal
Journal of Allergy and Clinical Immunology
Volume
133
Issue
2
Pages
AB88
Publisher
Elsevier
Description
Methods
This case-control study comprised 89 children with established diagnosis of AD and 139 healthy controls. Single nucleotide polymorphisms at IL-4-1098T> G (rs243248),-590C> T (rs2243250),-33C> T (rs2070874), and TGF-β codon10C> T (rs1982073) and codon25G> C (rs1800471) were typed. Frequencies of alleles, genotypes and haplotypes were estimated and compared between patients and controls.
Results
Patients with AD had significantly higher percentage of T allele at IL-4-1098T> G (84.4%) and C allele at IL-4-590C> T (85.0%) and IL-4-33C> T (84.4%, all p< 0.001). TT genotype at IL-4-1098T> G [OR 3.65, 95% CI (1.99-6.71)] and CC genotype at both IL-4-590C> T [OR 31.75, 95% CI (13.61-76.07)] and IL-4-33C> T [OR 3.52, 95% CI (1.92-6.52)] were overrepresented in AD patients (p< 0.001). Consistently, TCC haplotype was significantly more frequent in AD patients [(OR 5.15, 95% CI (3.28 …
Scholar articles
N Rezaei, Z Aryan, N Behniafard, E Farhadi… - Journal of Allergy and Clinical Immunology, 2014