Authors
MJ Mahmoudi, M Taghvaei, S Harsini, AA Amirzargar, M Hedayat, M Mahmoudi, E Nematipour, E Farhadi, N Esfahanian, M Sadr, K Nourijelyani, N Rezaei
Publication date
2016/1/1
Journal
Bratislavske Lekarske Listy
Volume
117
Issue
7
Pages
367-370
Description
Background
Proinflammatory cytokines have been known to play a considerable part in the pathomechanisms of chronic heart failure (CHF). Given the importance of proinflammatory cytokines in the context of the failing heart, we assessed whether the polymorphisms of interleukin (IL)-1 gene cluster, including IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1RA) and IL-1R gene are predictors of CHF due to ischemic heart disease.
Methods
Forty-three patients with ischemic heart failure were recruited in this study as patients group and compared with 140 healthy unrelated control subjects. Using polymerase chain reaction with sequence-specific primers method, the allele and genotype frequency of 5 single nucleotide polymorphisms (SNPs) within the IL-1α (-889), IL-1β (-511,+ 3962), IL-1R (psti 1970), and IL-1RA (mspa1 11100) genes were determined.
Results
The frequency of the IL-1β-511/C allele was significantly higher in the patient group compared to that in the control group (p= 0.031). The IL-1β (-511) C/C genotype was significantly overrepresented in patients compared to controls (p= 0.022).
Conclusions
Particular allele and genotype in IL-1β gene were overrepresented in patients with ischemic heart failure, possibly affecting the individual susceptibility to this disease (Tab. 1, Ref. 27).
Total citations
2020202132
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