Authors
N Behniafard, M Gharagozlou, S Sotoudeh, E Farhadi, M Khaledi, ZG Moghaddam, M Mahmoudi, SM Fathi, B Darabi, A Aghamohammadi, AA Amirzargar, N Rezaei
Publication date
2014/5/1
Journal
Allergologia et Immunopathologia
Volume
42
Issue
3
Pages
212-215
Publisher
No longer published by Elsevier
Description
Background
Interleukin-1 (IL-1) seems to have an important role in early reactions towards microbes, while its genetic variability could affect this role in atopic patients who have a distressed immunity towards dermatological infections.
Methods
Eighty-nine patients with atopic dermatitis (AD), who were referred to a main referral paediatric hospital, were enrolled in this study. Single nucleotide polymorphisms (SNP) of the following IL-1 cluster genes were assessed in this group of patients: IL-1α −889, IL-1β −511, IL-1β +3962, IL-1R Pst-I 1970, and IL-1RA Mspa-I 11100. The results were compared with a group of 140 healthy subjects from the same region.
Results
Fourteen percent of the controls had TT homozygous genotype in IL-1R at position Pst-I 1970, while only 2% of the patients with AD had this genotype (p = 0.005, OR: 0.14, 95%CI: 0.02–0.64). The CC homozygous genotype was the most common genotype in …
Scholar articles
N Behniafard, M Gharagozlou, S Sotoudeh, E Farhadi… - Allergologia et Immunopathologia, 2014