Authors
Masoud Movahedi, Ali Akbar Amirzargar, Rasoul Nasiri, Armin Hirbod-Mobarakeh, Elham Farhadi, Marzieh Tavakol, Nasrin Behniafard, Bita Ansaripour, Batoul Moradi, Ahad Zare, Nima Rezaei
Publication date
2013/11/1
Journal
American journal of otolaryngology
Volume
34
Issue
6
Pages
676-681
Publisher
WB Saunders
Description
Background
Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. T-helper (Th)2 cytokines seems to have major roles behind the scene of unpleasant symptoms resulted from AR. Expression of interleukin (IL)-4 and its receptor could be affected by single nucleotide polymorphisms (SNPs). This study assessed the effect of 4 genetic variants within genes of IL-4 and IL-4R in AR.
Methods
Allele frequencies of one IL-4R variant (rs1801275) and three SNPs of IL-4 (rs2243248, rs2243250, and rs2070874) were investigated in 98 patients with AR, compared to a group of controls, using PCR sequence-specific-primers (PCR-SSP) method.
Results
Homozygosity for the C allele of rs2243250 in IL-4 was significantly overrepresented in the patient group. CC genotype in rs2070874 significantly was correlated with AR. GG/CC/CC and TT/TT/TT (rs2243248, rs2243250, and rs2070874) haplotypes in the IL-4 gene …
Scholar articles
M Movahedi, AA Amirzargar, R Nasiri… - American journal of otolaryngology, 2013