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Image super-resolution (SR) aims to recover high-resolution images from their low-resolution counterparts for improving image analysis and visualization. Interpolation methods, widely used for this purpose, often result in images with blurred edges and blocking effects. More advanced methods such as total variation (TV) retain edge sharpness during image recovery. However, these methods only utilize information from local neighborhoods, neglecting useful information from remote voxels. In this paper, we propose a novel image SR method that integrates both local and global information for effective image recovery. This is achieved by, in addition to TV, low-rank regularization that enables utilization of information throughout the image. The optimization problem can be solved effectively via alternating direction method of multipliers (ADMM). Experiments on MR images of both adult and pediatric subjects …