Authors
Jing Jing, Yijun Zhou, Yuesong Pan, Xueli Cai, Wanlin Zhu, Zhe Zhang, Zixiao Li, Chang Liu, Xia Meng, Jian Cheng, Yilong Wang, Hao Li, Zhenzhou Wu, Suying Wang, Haijun Niu, Wei Wen, Tao Liu, Tiemin Wei, Yongjun Wang, Perminder S Sachdev
Publication date
2022/8/1
Journal
EBioMedicine
Volume
82
Publisher
Elsevier
Description
Background
White matter (WM) microstructural abnormalities have been observed in diabetes. However, evidence of prediabetes is currently lacking. This study aims to investigate the WM integrity in prediabetes and diabetes. We also assess the association of WM abnormalities with glucose metabolism status and continuous glucose measures.
Methods
The WM integrity was analyzed using cross-sectional baseline data from a population-based PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study. The cohort, including a total of 2218 cases with the mean age of 61.3 ± 6.6 years and 54.1% female, consisted of 1205 prediabetes which are categorized into two subgroups (a group of 254 prediabetes with combined impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and the other group of 951 prediabetes without combined IFG/IGT), 504 diabetes, and 509 normal …
Total citations
Scholar articles
Reduced white matter microstructural integrity in prediabetes and diabetes: a population-based study
J Jing, Y Zhou, Y Pan, X Cai, W Zhu, Z Zhang, Z Li… - EBioMedicine, 2022