Authors
Jing Jing, Chang Liu, Wanlin Zhu, Yuesong Pan, Jiyang Jiang, Xueli Cai, Zhe Zhang, Zixiao Li, Yijun Zhou, Xia Meng, Jian Cheng, Yilong Wang, Hao Li, Yong Jiang, Huaguang Zheng, Suying Wang, Haijun Niu, Wei Wen, Perminder S Sachdev, Tiemin Wei, Tao Liu, Yongjun Wang
Publication date
2023/4/1
Journal
Diabetes Care
Volume
46
Issue
4
Pages
819-827
Publisher
American Diabetes Association
Description
OBJECTIVE
To investigate the contribution of alterations in brain structure and function to cognitive function and their interactions in individuals with diabetes and patients with type 2 diabetes mellitus (T2DM).
RESEARCH DESIGN AND METHODS
This population-based study included 2,483 participants who underwent structural MRI (n = 569 with normal glucose metabolism [NGM], n = 1,353 with prediabetes, and n = 561 with T2DM) and cognitive testing. Of these, 2145 participants also underwent functional MRI (n = 496 NGM, n = 1,170 prediabetes, and n = 479 T2DM). Multivariate linear regression models were used to assess the association of brain volume and functional connectivity with cognition, as well as the association of brain volume and functional connectivity.
RESULTS
Compared with NGM participants, those with T2DM had lower brain volume in …
Total citations
20242
Scholar articles
J Jing, C Liu, W Zhu, Y Pan, J Jiang, X Cai, Z Zhang… - Diabetes Care, 2023