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Various coagulation disorders have been reported to explain hypercoagulability state in Behcet's disease (BD). A possible negative association between human leukocyte antigen (HLA)‐B51 and increased homocysteine level has been suggested in a previous report from Iranian patients with BD. The aim of this study was to find any possible relationship between plasma homocysteine levels and HLA‐B51.

In a case‐control study, BD patients (fulfilling the new International Criteria for BD) and controls (who had similar clinical symptoms but BD was clinically excluded in them) were included. Mean plasma homocysteine levels measured by enzyme‐linked immunosorbent assay in HLA‐B51 positive and negative individuals both in patients and controls were compared by t‐test, Mann–Whitney test and analysis of variance (F‐test).

Ninety‐six BD patients and 152 controls were …