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Introduction: Physical training, especially aerobic exercise combined with mental training by patients with Systemic Lupus Erythematosus (SLE), has numerous benefits, including tissue generation and enhanced anti-inflammatory activity. This study aimed at investigating the effect of ten-week aerobic-cognitive combined training on the serum levels of High Sensitivity C-Reactive Protein (HS-CRP), Anti-cardiolipin antibodies, Immunoglobulin G (IgG), Immunoglobulin M (IgM), and mental status of female SLE patients.

Materials and Methods: Eight female patients with SLE (with the Mean±SD age of 50±47.04 year and the Mean±SD BMI of 29.57±5.83 kg/m2) were randomly assigned to the experimental (n= 5) and control (n= 3) groups. The experimental group performed Brailletonik exercise, including aerobic (60-80% of Max HR) and cognitive training for ten weeks. The serum levels of HS-CRP, IgG, IgM, and mental status of the patients were evaluated in both groups before and after the training.

Results: According to the results of 2× 2 mixed Analysis of Covariance (ANCOVA), there was no significant effect of training on the serum levels of HS-CRP, IgG, and IgM (P> 0.05), but HS-CRP and IgM level decreased in the experimental group by (42%) and (23.5%), respectively. The result of ANCOVA indicated the significant effect of training on mental status (P= 0.005).

Conclusion: Physical combined cognitive training could be more effective in improving the mental status compared to a decrease in serum inflammatory factors of SLE patients.