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Behçet’s disease (BD) is a chronic inflammatory disease characterized by oral aphthous ulcers, genital ulcers, uveitis and skin lesions. Etiology and pathogenesis of BD are not fully elucidated, but the association with human leukocyte antigen (HLA)‐B51 or B*5101 has been repeatedly reported. Previous studies have shown that there are few sequence variations in the protein‐coding region of B51, while there is a report on many variations in the 5′‐flanking region and intron. In this study, HLA‐B*5101 gene from 37 individuals including Japanese, Turkish, Jordanian and Iranian patients and healthy controls were fully sequenced to further clarify the B*5101 gene in association with BD. We found that all the patients and healthy controls carried B*510101 with no variation in the 5′‐flanking region, exon and intron. However, seven polymorphisms were found in the 3′‐flanking region. These polymorphisms …