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Blood clot during hemodielysis is a reason for blood loss and interference in hemodialysis solution clearance. Therefore during hemodialysis HEPARIN is used for anticoagulation. The aim of this study is to compare the effect of HEPARIN versus FRAGMIN (a type of low molecular weight HEPARIN) on serum lipid levels. This is an experimental research performed on two groups of patients on hemodialysis. In group I, there were 11 patients (5 men and 6 women) with average age of 62.5 years old and average of 76.8 months duration of hemodialysis therapy in 15 th Khordad Hospital Hemodialysis Center; all received the same dose of HEPARIN. In group II, there were 11 patients (5 men and 6 women) with average age 55.6 years old and average duration of hemodialysis was 80.8 months performed in the same center. They all received the same dose of FRAGMIN, for 9 months continuously. None of the patients in either group received lipid lowering drugs. At times 0, 3, 6 and 9 months, serum levels of CHOLESTEROL, TRIGLYCERIDE, HLD and LDL of all patients were checked. With the hypothesis that FRAGMIN does not have the hyperlipidemic effect of HEPARIN, the HEPARIN used group was selected as" control group" and the FRAGMIN used group was selected as" experimental group". T-test was used for data analysis. The results of study show that there was no significant difference between serum CHOLESTEROL levels of these two groups (p= 0.59). There was no significant difference between serum TRIGLYCERIDE levels of two groups (p= 0.18). Similar results were seen with LDL (p …