Authors
F DAVATCHI
Publication date
2006/4/11
Journal
Adamantiades-Behçet's Disease
Volume
528
Pages
487
Publisher
Springer Science & Business Media
Description
Ocular manifestations are one of the main features of Behcet’s Disease (BD). They occur in more than half of the patients. In our series they were seen in 58% of cases1. The natural course of ocular manifestations ‚like other manifestations of BD ‚is a progression by repetitive attacks followed by remission. However ‚in contrast to other lesions (mucocutaneous)‚the remission is much slower in posterior uveitis ‚and practically absent in retinal vasculitis. Usually the healing process is not completed before the next attack. Therefore ‚lesions accumulate during successive attacks and lead to severe loss of vision ‚or blindness2.
A treatment will have 2 goals: 1) Combat the inflammation. Prednisolone is the best choice ‚1/2 to 1 mg/kg/daily is the necessary dose. 2) Control the autoimmune disorder and prevent from further attacks. There is a large choice of drugs on this purpose. Immunomodulators such as cyclosporine A ‚many cytotoxic drugs (cyclophosphamide ‚chlorambucil ‚azathioprine ‚methotrexate)‚and recently biologic agents anti-TNF drugs) can meet these requirements.
Scholar articles
F DAVATCHI - Adamantiades-Behçet's Disease, 2006