Authors
John Darmawan, A Remy Nasution, Dongbao Zhao, Sun-le Chen, Tran Thi Minh Hoa, Syed Atiqul Haq, Qingyu Zeng, Fereydoun Davatchi, Budi Liem
Journal
Prospective Observational Analysis of Efficacies and Adverse Effects. Submitted for review and publication
Description
Objective. To assess 7 years outcome of Biopsy-proven Lupus Nephritis.
Materials and Methods. The 35 consecutive patients with Biopsy-proven WHO Class III, IV, and V Lupus Nephritis were enrolled in a 7-years prospective observational study. The Step-down Bridge Protocol of Intravenous and Oral Combination of 5 Immunosuppressants was empirically applied when the SLAM Score was> 4, Chronicity Index< 5 or Lupus Prognosis Index< 5, and ESR> 40 mm.
Results. Remission was induced by the intravenous therapy in 2-4 months. Remission with oral Drugs was achieved in 5.5-7.5 months after the intravenous therapy was tapered off. Remission was consolidated for at least 2 years, before tapering off oral drugs over 1 year. Remission without Drug was ultimately obtained after 3.5–4.5 years in Immunosuppressant-naïve Lupus Nephritis. Not immunosuppressant-naïve Lupus Nephritis remained in …
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