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The performance of ISG criteria versus ICBD original and ICBD revised criteria were checked in different cohort of patients (BD versus Control patients). These cohorts were: India (50 BD), Singapore (37 BD), Iran 2004 (4900 BD, 2020 controls), the cohort of International patients for the creation of ICBD (2556 BD/1163 controls), Germany (86 BD, 38 controls), China (322 BD, 118 controls), Iran 2010 (6128 BD, 3400 controls), and Iran 2013 (7011 BD, 5226 controls). The sensitivity of the ISG/ICBD/rICBD criteria in the cohort of India was 72%/100%/100%, in Singapore 46%/86.5%/86.5%, Iran-2004 82%/97.5%/95%, ICBD 82.4%/96.1%/96%, Germany 83.7%/96.5%/?, China 65.4%/87%/?, Iran-2010 78.1%/98.2%/96.4%, and Iran-2013 77.5%/98.3%/96.8%. The specificity in the cohort of Iran-2004 was 98%/93.6%/95.7%, ICBD 96%/88.7%/91.2%, Germany 89.5%/73.7%/?, China 99.2%/94.1%/?, Iran-2010 98.8%/95.6%/97.1%, Iran-2013 99.2%/96.2%/97.2%. The Accuracy in the cohort of Iran-2004 was 87.1%/97%/96.1%, ICBD 86.7%/93.8%/94.5%, Germany 85.5%/89.5%/?, China 74.2%/88.9%/?, Iran-2010 85.5%/97.3%/97.4%, Iran-2013 86.8%/97.4%/97%.

The diagnosis may become easy, by using good classification/Diagnosis criteria, especially for a non-expert. Unfortunately, in Behcet’s Disease, some of the clinical manifestations of the criteria, are also seen frequently in the normal population (oral aphthous ulcers), or may be seen in other diseases too (Erythema nodosum, ocular manifestations). Therefore, diagnostic errors may become frequent by non-experts. To avoid misdiagnosis, it is customary to say that when a patient fulfills the …