Authors
C Chams‐Davatchi, A Mortazavizadeh, M Daneshpazhooh, F Davatchi, K Balighi, N Esmaili, M Akhyani, Z Hallaji, H Seirafi, H Mortazavi
Publication date
2013/10
Journal
Journal of the European Academy of Dermatology and Venereology
Volume
27
Issue
10
Pages
1285-1292
Publisher
Blackwell Publishing Ltd
Description
Background  The classic treatment for pemphigus vulgaris is prednisolone. Immunosuppressive drugs can be used in association.
Objective  To compare the efficacy of Azathioprine in reducing the Disease Activity Index (DAI).
Patients and methods  A double blind randomized controlled study was conducted on 56 new patients, assigned to two therapeutic groups: (i) prednisolone plus placebo; (ii) prednisolone plus Azathioprine. Patients were checked regularly for 1 year. ‘Complete remission’ was defined as healing of all lesions after 12 months, and prednisolone <7.5 mg daily, (DAI ≤ 1). Analysis was done by ‘Intention To Treat’ (ITT) and ‘Treatment Completed Analysis’ (TCA).
Results  Both groups were similar in age, gender, disease duration, and DAI. Primary endpoint: By ITT and TCA, the mean DAI improved in both groups with no significant difference between them. The difference became …
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